Skip to main content

Exercise training changes IL-10/TNF-alpha ratio in the skeletal muscle of post-MI rats.

Publication ,  Journal Article
Batista, ML; Rosa, JC; Lopes, RD; Lira, FS; Martins, E; Yamashita, AS; Brum, PC; Lancha, AH; Lopes, AC; Seelaender, M
Published in: Cytokine
January 2010

Heart failure (HF) is associated with changes in the skeletal muscle (SM) which might be a consequence of the unbalanced local expression of pro- (TNF-alpha) and anti- (IL-10) inflammatory cytokines, leading to inflammation-induced myopathy, and SM wasting. This local effect of HF on SM may, on the other hand, contribute to systemic inflammation, as this tissue actively secretes cytokines. Since increasing evidence points out to an anti-inflammatory effect of exercise training, the goal of the present study was to investigate its effect in rats with HF after post-myocardial infarction (MI), with special regard to the expression of TNF-alpha and IL-10 in the soleus and extensor digitorum longus (EDL), muscles with different fiber composition. Wistar rats underwent left thoracotomy with ligation of the left coronary artery, and were randomly assigned to either a sedentary (Sham-operated and MI sedentary) or trained (Sham-operated and MI trained) group. Animals in the trained groups ran on a treadmill (0% grade at 13-20 m/min) for 60 min/day, 5 days/week, for 8-10 weeks. The training protocol was able to reverse the changes induced by MI, decreasing TNF-alpha protein (26%, P<0.05) and mRNA (58%, P<0.05) levels in the soleus, when compared with the sedentary MI group. Training also increased soleus IL-10 expression (2.6-fold, P<0.001) in post-MI HF rats. As a consequence, the IL-10/TNF-alpha ratio was increased. This "anti-inflammatory effect" was more pronounced in the soleus than in the EDL, suggesting a fiber composition dependent response.

Duke Scholars

Published In

Cytokine

DOI

EISSN

1096-0023

Publication Date

January 2010

Volume

49

Issue

1

Start / End Page

102 / 108

Location

England

Related Subject Headings

  • Tumor Necrosis Factor-alpha
  • Rats, Wistar
  • Rats
  • Random Allocation
  • Physical Conditioning, Animal
  • Organ Size
  • Myocardial Infarction
  • Muscle, Skeletal
  • Male
  • Interleukin-10
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Batista, M. L., Rosa, J. C., Lopes, R. D., Lira, F. S., Martins, E., Yamashita, A. S., … Seelaender, M. (2010). Exercise training changes IL-10/TNF-alpha ratio in the skeletal muscle of post-MI rats. Cytokine, 49(1), 102–108. https://doi.org/10.1016/j.cyto.2009.10.007
Batista, M. L., J. C. Rosa, R. D. Lopes, F. S. Lira, E. Martins, A. S. Yamashita, P. C. Brum, A. H. Lancha, A. C. Lopes, and M. Seelaender. “Exercise training changes IL-10/TNF-alpha ratio in the skeletal muscle of post-MI rats.Cytokine 49, no. 1 (January 2010): 102–8. https://doi.org/10.1016/j.cyto.2009.10.007.
Batista ML, Rosa JC, Lopes RD, Lira FS, Martins E, Yamashita AS, et al. Exercise training changes IL-10/TNF-alpha ratio in the skeletal muscle of post-MI rats. Cytokine. 2010 Jan;49(1):102–8.
Batista, M. L., et al. “Exercise training changes IL-10/TNF-alpha ratio in the skeletal muscle of post-MI rats.Cytokine, vol. 49, no. 1, Jan. 2010, pp. 102–08. Pubmed, doi:10.1016/j.cyto.2009.10.007.
Batista ML, Rosa JC, Lopes RD, Lira FS, Martins E, Yamashita AS, Brum PC, Lancha AH, Lopes AC, Seelaender M. Exercise training changes IL-10/TNF-alpha ratio in the skeletal muscle of post-MI rats. Cytokine. 2010 Jan;49(1):102–108.

Published In

Cytokine

DOI

EISSN

1096-0023

Publication Date

January 2010

Volume

49

Issue

1

Start / End Page

102 / 108

Location

England

Related Subject Headings

  • Tumor Necrosis Factor-alpha
  • Rats, Wistar
  • Rats
  • Random Allocation
  • Physical Conditioning, Animal
  • Organ Size
  • Myocardial Infarction
  • Muscle, Skeletal
  • Male
  • Interleukin-10