T-bet-dependent expression of osteopontin contributes to T cell polarization.

Published

Journal Article

The osteopontin (Opn) glycoprotein has been implicated in diverse physiological processes, including vascularization, bone formation, and inflammatory responses. Studies of its role in immune responses has suggested that Opn can set the early stage of type-1 immune (cell-mediated) responses through differential regulation of IL-12 and IL-10 cytokine gene expression in macrophages. Although Opn has been suggested to play a role in the development of type-1 immunity, little is known about control of Opn gene expression. Here, we report that Opn gene expression in activated T cells, but not macrophages, is regulated by T-bet, a transcription factor that controls CD4+ T helper (Th1) cell lineage commitment. We also find that T-bet-dependent expression of Opn in T cells is essential for efficient skewing of CD4+ T and CD8+ T cells toward the Th1 and type 1 CD8+ T cells (Tc1) pathway, respectively. Taken together, these findings begin to delineate the genetic basis of Opn expression in T cells and further clarify the role of Opn in Th and Tc1 development.

Full Text

Duke Authors

Cited Authors

  • Shinohara, ML; Jansson, M; Hwang, ES; Werneck, MBF; Glimcher, LH; Cantor, H

Published Date

  • November 22, 2005

Published In

Volume / Issue

  • 102 / 47

Start / End Page

  • 17101 - 17106

PubMed ID

  • 16286640

Pubmed Central ID

  • 16286640

International Standard Serial Number (ISSN)

  • 0027-8424

Digital Object Identifier (DOI)

  • 10.1073/pnas.0508666102

Language

  • eng

Conference Location

  • United States