Analysis of regulatory CD8 T cells in Qa-1-deficient mice.

Published

Journal Article

The mouse protein Qa-1 (HLA-E in humans) is essential for immunological protection and immune regulation. Although Qa-1 has been linked to CD8 T cell-dependent suppression, the physiological relevance of this observation is unclear. We generated mice deficient in Qa-1 to develop an understanding of this process. Qa-1-deficient mice develop exaggerated secondary CD4 responses to foreign and self peptides. Enhanced responses to proteolipid protein self peptide were associated with resistance of Qa-1-deficient CD4 T cells to Qa-1-restricted CD8 T suppressor activity and increased susceptibility to experimental autoimmune encephalomyelitis. These findings delineate a Qa-1-dependent T cell-T cell inhibitory interaction that prevents the pathogenic expansion of autoreactive CD4 T cell populations and consequent autoimmune disease.

Full Text

Duke Authors

Cited Authors

  • Hu, D; Ikizawa, K; Lu, L; Sanchirico, ME; Shinohara, ML; Cantor, H

Published Date

  • May 2004

Published In

Volume / Issue

  • 5 / 5

Start / End Page

  • 516 - 523

PubMed ID

  • 15098030

Pubmed Central ID

  • 15098030

International Standard Serial Number (ISSN)

  • 1529-2908

Digital Object Identifier (DOI)

  • 10.1038/ni1063

Language

  • eng

Conference Location

  • United States