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Intracellular osteopontin (iOPN) and immunity.

Publication ,  Journal Article
Inoue, M; Shinohara, ML
Published in: Immunol Res
April 2011

Osteopontin (OPN) is a protein involved in various pathophysiological events. OPN has been studied as a secreted protein, but recent reports showed that OPN can be found in the cytoplasm and the nucleus. Therefore, some OPN molecules are not secreted and stay in cells. Such intracellular OPN (iOPN) has biological functions distinct from secreted OPN (sOPN). iOPN is involved in cytoskeletal rearrangement and in signal transduction pathways downstream of innate immune receptors, such as Toll-like receptors (TLRs), as an adaptor or scaffolding protein. Although sOPN and iOPN are generated from the same Opn mRNA species, biological outcomes mediated by two isoforms can be different. It would be necessary to delineate which isoform of OPN is responsible for pathophysiological events.

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Published In

Immunol Res

DOI

EISSN

1559-0755

Publication Date

April 2011

Volume

49

Issue

1-3

Start / End Page

160 / 172

Location

United States

Related Subject Headings

  • Toll-Like Receptors
  • Signal Transduction
  • Osteopontin
  • Intracellular Space
  • Immunology
  • Immunity, Innate
  • Humans
  • Cell Adhesion
  • Animals
  • 3204 Immunology
 

Citation

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Inoue, M., & Shinohara, M. L. (2011). Intracellular osteopontin (iOPN) and immunity. Immunol Res, 49(1–3), 160–172. https://doi.org/10.1007/s12026-010-8179-5
Inoue, Makoto, and Mari L. Shinohara. “Intracellular osteopontin (iOPN) and immunity.Immunol Res 49, no. 1–3 (April 2011): 160–72. https://doi.org/10.1007/s12026-010-8179-5.
Inoue M, Shinohara ML. Intracellular osteopontin (iOPN) and immunity. Immunol Res. 2011 Apr;49(1–3):160–72.
Inoue, Makoto, and Mari L. Shinohara. “Intracellular osteopontin (iOPN) and immunity.Immunol Res, vol. 49, no. 1–3, Apr. 2011, pp. 160–72. Pubmed, doi:10.1007/s12026-010-8179-5.
Inoue M, Shinohara ML. Intracellular osteopontin (iOPN) and immunity. Immunol Res. 2011 Apr;49(1–3):160–172.
Journal cover image

Published In

Immunol Res

DOI

EISSN

1559-0755

Publication Date

April 2011

Volume

49

Issue

1-3

Start / End Page

160 / 172

Location

United States

Related Subject Headings

  • Toll-Like Receptors
  • Signal Transduction
  • Osteopontin
  • Intracellular Space
  • Immunology
  • Immunity, Innate
  • Humans
  • Cell Adhesion
  • Animals
  • 3204 Immunology