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Arrhythmogenic right ventricular cardiomyopathy/dysplasia clinical presentation and diagnostic evaluation: results from the North American Multidisciplinary Study.

Publication ,  Journal Article
Marcus, FI; Zareba, W; Calkins, H; Towbin, JA; Basso, C; Bluemke, DA; Estes, NAM; Picard, MH; Sanborn, D; Thiene, G; Wichter, T; Cannom, D ...
Published in: Heart Rhythm
July 2009

BACKGROUND: Prior reports on patients with arrhythmogenic right ventricular cardiomyopathy/dysplasia (ARVC/D) focused on individuals with advanced forms of the disease. Data on the diagnostic performance of various testing modalities in newly identified individuals suspected of having ARVC/D are limited. OBJECTIVE: The purpose of the Multidisciplinary Study of Arrhythmogenic Right Ventricular Cardiomyopathy/Dysplasia was to study the clinical characteristics and diagnostic evaluation of a large group of patients newly identified with ARVC/D. METHODS: A total of 108 newly diagnosed patients with suspected ARVC/D were prospectively enrolled in the United States and Canada. The patients underwent noninvasive and invasive tests using standardized protocols that initially were interpreted by the enrolling center and adjudicated by blind analysis in six core laboratories. Patients were followed for a mean of 27 +/- 16 months (range 0.2-63 months). RESULTS: The clinical profile of these newly diagnosed patients differs from the profile of reported patients with more advanced disease. There was considerable difference in the initial and final classification of the presence of ARVC/D after the diagnostic tests were evaluated by the core laboratories. Final clinical diagnosis was 73 affected, 28 borderline, and 7 unaffected. Individual tests agreed with the final diagnosis in 50% to 70% of the 73 patients with a final classification of affected. CONCLUSION: The clinical profile of 108 newly diagnosed probands with suspected ARVC/D indicates that a combination of diagnostic tests is needed to evaluate the presence of right ventricular structural, functional, and electrical abnormalities. Echocardiography, right ventricular angiography, signal-averaged ECG, and Holter monitoring provide optimal clinical evaluation of patients suspected of ARVC/D.

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Published In

Heart Rhythm

DOI

EISSN

1556-3871

Publication Date

July 2009

Volume

6

Issue

7

Start / End Page

984 / 992

Location

United States

Related Subject Headings

  • Young Adult
  • United States
  • Prospective Studies
  • Middle Aged
  • Male
  • Humans
  • Female
  • Electrocardiography, Ambulatory
  • Electrocardiography
  • Echocardiography
 

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Marcus, F. I., Zareba, W., Calkins, H., Towbin, J. A., Basso, C., Bluemke, D. A., … McNitt, S. (2009). Arrhythmogenic right ventricular cardiomyopathy/dysplasia clinical presentation and diagnostic evaluation: results from the North American Multidisciplinary Study. Heart Rhythm, 6(7), 984–992. https://doi.org/10.1016/j.hrthm.2009.03.013
Marcus, Frank I., Wojciech Zareba, Hugh Calkins, Jeffrey A. Towbin, Cristina Basso, David A. Bluemke, NA Mark Estes, et al. “Arrhythmogenic right ventricular cardiomyopathy/dysplasia clinical presentation and diagnostic evaluation: results from the North American Multidisciplinary Study.Heart Rhythm 6, no. 7 (July 2009): 984–92. https://doi.org/10.1016/j.hrthm.2009.03.013.
Marcus FI, Zareba W, Calkins H, Towbin JA, Basso C, Bluemke DA, et al. Arrhythmogenic right ventricular cardiomyopathy/dysplasia clinical presentation and diagnostic evaluation: results from the North American Multidisciplinary Study. Heart Rhythm. 2009 Jul;6(7):984–92.
Marcus, Frank I., et al. “Arrhythmogenic right ventricular cardiomyopathy/dysplasia clinical presentation and diagnostic evaluation: results from the North American Multidisciplinary Study.Heart Rhythm, vol. 6, no. 7, July 2009, pp. 984–92. Pubmed, doi:10.1016/j.hrthm.2009.03.013.
Marcus FI, Zareba W, Calkins H, Towbin JA, Basso C, Bluemke DA, Estes NAM, Picard MH, Sanborn D, Thiene G, Wichter T, Cannom D, Wilber DJ, Scheinman M, Duff H, Daubert J, Talajic M, Krahn A, Sweeney M, Garan H, Sakaguchi S, Lerman BB, Kerr C, Kron J, Steinberg JS, Sherrill D, Gear K, Brown M, Severski P, Polonsky S, McNitt S. Arrhythmogenic right ventricular cardiomyopathy/dysplasia clinical presentation and diagnostic evaluation: results from the North American Multidisciplinary Study. Heart Rhythm. 2009 Jul;6(7):984–992.
Journal cover image

Published In

Heart Rhythm

DOI

EISSN

1556-3871

Publication Date

July 2009

Volume

6

Issue

7

Start / End Page

984 / 992

Location

United States

Related Subject Headings

  • Young Adult
  • United States
  • Prospective Studies
  • Middle Aged
  • Male
  • Humans
  • Female
  • Electrocardiography, Ambulatory
  • Electrocardiography
  • Echocardiography