Moxifloxacin-induced torsades de pointes.
Journal Article (Journal Article)
Torsade de pointes (TdP) is increasingly recognized as a complication of drug therapy. The most common cause of drug-induced QT prolongation is inhibition of the rapidly activating component of the delayed potassium current (I(Kr)). Moxifloxacin, a widely used fluoroquinolone, is a weak I(Kr) inhibitor and has been associated with QT prolongation. We report a case of marked QT prolongation (618 ms) and TdP associated with moxifloxacin use. Although it is difficult to predict which patients are at risk from TdP, careful assessment of the risk/benefit ratio is important before prescribing drugs known to cause QT prolongation.
Full Text
Duke Authors
Cited Authors
- Sherazi, S; DiSalle, M; Daubert, JP; Shah, AH
Published Date
- 2008
Published In
Volume / Issue
- 15 / 1
Start / End Page
- 71 - 73
PubMed ID
- 18651388
Electronic International Standard Serial Number (EISSN)
- 1898-018X
Language
- eng
Conference Location
- Poland