Traversing the valley of death: a guide to assessing prospects for translational success.

Journal Article (Journal Article)

On the basis of our experience in drug and device development, we have identified six broad categories of issues that profoundly affect the probability for successful translation of basic scientific discoveries into effective therapies. Within each category, we propose a series of questions that form the beginnings of a self-guided global risk assessment tool. Although this preliminary tool will require validation and adjustment, we offer it to stimulate a discussion about more rigorous methods for selecting and conducting translational projects.

Full Text

Duke Authors

Cited Authors

  • Coller, BS; Califf, RM

Published Date

  • December 9, 2009

Published In

Volume / Issue

  • 1 / 10

Start / End Page

  • 10cm9 -

PubMed ID

  • 20368156

Pubmed Central ID

  • 20368156

Electronic International Standard Serial Number (EISSN)

  • 1946-6242

Digital Object Identifier (DOI)

  • 10.1126/scitranslmed.3000265


  • eng

Conference Location

  • United States