The extracellular matrix protein mindin is a pattern-recognition molecule for microbial pathogens.

Published

Journal Article

Microbial pathogens use a variety of their surface molecules to bind to host extracellular matrix (ECM) components to establish an effective infection. However, ECM components can also serve as an integral part of the innate immunity. Mice lacking expression of mindin (spondin 2), a highly conserved ECM protein, have an impaired ability to clear bacterial infection, and mindin-deficient macrophages show defective responses to a broad spectrum of microbial stimuli. Moreover, mindin binds directly to bacteria and their components and functions as an opsonin for macrophage phagocytosis of bacteria. Thus, mindin is essential in the initiation of the innate immune response and represents a unique pattern-recognition molecule in the ECM for microbial pathogens.

Full Text

Duke Authors

Cited Authors

  • He, Y-W; Li, H; Zhang, J; Hsu, C-L; Lin, E; Zhang, N; Guo, J; Forbush, KA; Bevan, MJ

Published Date

  • January 2004

Published In

Volume / Issue

  • 5 / 1

Start / End Page

  • 88 - 97

PubMed ID

  • 14691481

Pubmed Central ID

  • 14691481

Electronic International Standard Serial Number (EISSN)

  • 1529-2916

International Standard Serial Number (ISSN)

  • 1529-2908

Digital Object Identifier (DOI)

  • 10.1038/ni1021

Language

  • eng