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The extracellular matrix protein mindin is a pattern-recognition molecule for microbial pathogens.

Publication ,  Journal Article
He, Y-W; Li, H; Zhang, J; Hsu, C-L; Lin, E; Zhang, N; Guo, J; Forbush, KA; Bevan, MJ
Published in: Nat Immunol
January 2004

Microbial pathogens use a variety of their surface molecules to bind to host extracellular matrix (ECM) components to establish an effective infection. However, ECM components can also serve as an integral part of the innate immunity. Mice lacking expression of mindin (spondin 2), a highly conserved ECM protein, have an impaired ability to clear bacterial infection, and mindin-deficient macrophages show defective responses to a broad spectrum of microbial stimuli. Moreover, mindin binds directly to bacteria and their components and functions as an opsonin for macrophage phagocytosis of bacteria. Thus, mindin is essential in the initiation of the innate immune response and represents a unique pattern-recognition molecule in the ECM for microbial pathogens.

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Published In

Nat Immunol

DOI

ISSN

1529-2908

Publication Date

January 2004

Volume

5

Issue

1

Start / End Page

88 / 97

Location

United States

Related Subject Headings

  • Teichoic Acids
  • Molecular Sequence Data
  • Mice, Knockout
  • Mice, Inbred C57BL
  • Mice
  • Male
  • Macrophages, Peritoneal
  • Lipopolysaccharides
  • Immunology
  • Humans
 

Citation

APA
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ICMJE
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He, Y.-W., Li, H., Zhang, J., Hsu, C.-L., Lin, E., Zhang, N., … Bevan, M. J. (2004). The extracellular matrix protein mindin is a pattern-recognition molecule for microbial pathogens. Nat Immunol, 5(1), 88–97. https://doi.org/10.1038/ni1021
He, You-Wen, Hong Li, Jun Zhang, Chia-Lin Hsu, Emily Lin, Nu Zhang, Jian Guo, Katherine A. Forbush, and Michael J. Bevan. “The extracellular matrix protein mindin is a pattern-recognition molecule for microbial pathogens.Nat Immunol 5, no. 1 (January 2004): 88–97. https://doi.org/10.1038/ni1021.
He Y-W, Li H, Zhang J, Hsu C-L, Lin E, Zhang N, et al. The extracellular matrix protein mindin is a pattern-recognition molecule for microbial pathogens. Nat Immunol. 2004 Jan;5(1):88–97.
He, You-Wen, et al. “The extracellular matrix protein mindin is a pattern-recognition molecule for microbial pathogens.Nat Immunol, vol. 5, no. 1, Jan. 2004, pp. 88–97. Pubmed, doi:10.1038/ni1021.
He Y-W, Li H, Zhang J, Hsu C-L, Lin E, Zhang N, Guo J, Forbush KA, Bevan MJ. The extracellular matrix protein mindin is a pattern-recognition molecule for microbial pathogens. Nat Immunol. 2004 Jan;5(1):88–97.

Published In

Nat Immunol

DOI

ISSN

1529-2908

Publication Date

January 2004

Volume

5

Issue

1

Start / End Page

88 / 97

Location

United States

Related Subject Headings

  • Teichoic Acids
  • Molecular Sequence Data
  • Mice, Knockout
  • Mice, Inbred C57BL
  • Mice
  • Male
  • Macrophages, Peritoneal
  • Lipopolysaccharides
  • Immunology
  • Humans