The antiapoptotic protein Bcl-xL is dispensable for the development of effector and memory T lymphocytes.
Journal Article (Journal Article)
The antiapoptotic protein Bcl-x(L) is induced in activated T lymphocytes upon costimulation through CD28, 4-1BB, and OX40. Bcl-x(L) is also highly enriched in memory T lymphocytes. Based on this body of evidence, it was thought that Bcl-x(L) plays an essential role in the generation of effector and memory T lymphocytes. We report that mice with a conditional deletion of Bcl-x in T lymphocytes develop a normal CD8(+) T cell response to Listeria monocytogenes infection. Furthermore, Bcl-x conditional knockout mice exhibit normal T-dependent humoral immune responses. These results indicate that Bcl-x is dispensable for the generation of effector and memory T lymphocytes and suggest that costimulation of T lymphocytes promotes their survival through a Bcl-x(L) independent mechanism.
- Zhang, N; He, Y-W
- June 1, 2005
Volume / Issue
- 174 / 11
Start / End Page
- 6967 - 6973
International Standard Serial Number (ISSN)
Digital Object Identifier (DOI)
- United States