The antiapoptotic protein Bcl-xL is dispensable for the development of effector and memory T lymphocytes.

Published

Journal Article

The antiapoptotic protein Bcl-x(L) is induced in activated T lymphocytes upon costimulation through CD28, 4-1BB, and OX40. Bcl-x(L) is also highly enriched in memory T lymphocytes. Based on this body of evidence, it was thought that Bcl-x(L) plays an essential role in the generation of effector and memory T lymphocytes. We report that mice with a conditional deletion of Bcl-x in T lymphocytes develop a normal CD8(+) T cell response to Listeria monocytogenes infection. Furthermore, Bcl-x conditional knockout mice exhibit normal T-dependent humoral immune responses. These results indicate that Bcl-x is dispensable for the generation of effector and memory T lymphocytes and suggest that costimulation of T lymphocytes promotes their survival through a Bcl-x(L) independent mechanism.

Full Text

Duke Authors

Cited Authors

  • Zhang, N; He, Y-W

Published Date

  • June 1, 2005

Published In

Volume / Issue

  • 174 / 11

Start / End Page

  • 6967 - 6973

PubMed ID

  • 15905539

Pubmed Central ID

  • 15905539

International Standard Serial Number (ISSN)

  • 0022-1767

Digital Object Identifier (DOI)

  • 10.4049/jimmunol.174.11.6967

Language

  • eng

Conference Location

  • United States