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Failure of serum transforming growth factor-beta (TGF-beta1) as a biomarker of radiographic osteoarthritis at the knee and hip: a cross-sectional analysis in the Johnston County Osteoarthritis Project.

Publication ,  Journal Article
Nelson, AE; Fang, F; Shi, XA; Kraus, VB; Stabler, T; Renner, JB; Schwartz, TA; Helmick, CG; Jordan, JM
Published in: Osteoarthritis Cartilage
June 2009

PURPOSE: To assess associations between serum transforming growth factor-beta (TGF-beta1) and radiographic knee and hip osteoarthritis (rOA) in African American (AA) and White men and women. METHODS: Baseline data from 330 participants in the Johnston County Osteoarthritis Project were used in the analysis. Radiographs were scored with the Kellgren-Lawrence scale and rOA defined as grade> or =2. Individual radiographic features (IRFs) were rated 0-3. TGF-beta1 was measured using a sandwich enzyme-linked immunosorbent assay (ELISA). General linear models were used to estimate associations between lnTGF-beta1 and rOA presence, laterality or severity, and IRF presence and severity, adjusting for age, gender, race and body mass index. Interactions by race and gender were considered significant at P<0.1. RESULTS: Mean lnTGF-beta1 levels were higher among AAs compared to Whites, and among women compared to men (P<0.009). Mean lnTGF-beta1 levels were higher in those with knee osteophytes (OST), but this association was not significant after adjustment. There were no other significant differences in mean lnTGF-beta1 levels by presence, laterality, or severity of knee or hip rOA or IRFs. No race or gender interactions were identified, although a borderline significant association between lnTGF-beta1 and knee OST was seen among AAs (P<0.06). CONCLUSIONS: Although serum TGF-beta1 varied by race and gender and several rOA variables, there were no independent significant associations with presence, laterality, or severity of knee or hip rOA by K-L grade or IRFs, suggesting that serum TGF-beta1 is unlikely to be useful as a stand-alone biomarker in OA studies. A possible association between TGF-beta1 and OST in AAs cannot be excluded.

Duke Scholars

Published In

Osteoarthritis Cartilage

DOI

EISSN

1522-9653

Publication Date

June 2009

Volume

17

Issue

6

Start / End Page

772 / 776

Location

England

Related Subject Headings

  • Weight-Bearing
  • Transforming Growth Factor beta1
  • Radiography
  • Osteoarthritis, Knee
  • Osteoarthritis, Hip
  • Middle Aged
  • Male
  • Knee Joint
  • Humans
  • Hip Joint
 

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Nelson, A. E., Fang, F., Shi, X. A., Kraus, V. B., Stabler, T., Renner, J. B., … Jordan, J. M. (2009). Failure of serum transforming growth factor-beta (TGF-beta1) as a biomarker of radiographic osteoarthritis at the knee and hip: a cross-sectional analysis in the Johnston County Osteoarthritis Project. Osteoarthritis Cartilage, 17(6), 772–776. https://doi.org/10.1016/j.joca.2008.11.010
Nelson, A. E., F. Fang, X. A. Shi, V. B. Kraus, T. Stabler, J. B. Renner, T. A. Schwartz, C. G. Helmick, and J. M. Jordan. “Failure of serum transforming growth factor-beta (TGF-beta1) as a biomarker of radiographic osteoarthritis at the knee and hip: a cross-sectional analysis in the Johnston County Osteoarthritis Project.Osteoarthritis Cartilage 17, no. 6 (June 2009): 772–76. https://doi.org/10.1016/j.joca.2008.11.010.
Nelson, A. E., et al. “Failure of serum transforming growth factor-beta (TGF-beta1) as a biomarker of radiographic osteoarthritis at the knee and hip: a cross-sectional analysis in the Johnston County Osteoarthritis Project.Osteoarthritis Cartilage, vol. 17, no. 6, June 2009, pp. 772–76. Pubmed, doi:10.1016/j.joca.2008.11.010.
Nelson AE, Fang F, Shi XA, Kraus VB, Stabler T, Renner JB, Schwartz TA, Helmick CG, Jordan JM. Failure of serum transforming growth factor-beta (TGF-beta1) as a biomarker of radiographic osteoarthritis at the knee and hip: a cross-sectional analysis in the Johnston County Osteoarthritis Project. Osteoarthritis Cartilage. 2009 Jun;17(6):772–776.
Journal cover image

Published In

Osteoarthritis Cartilage

DOI

EISSN

1522-9653

Publication Date

June 2009

Volume

17

Issue

6

Start / End Page

772 / 776

Location

England

Related Subject Headings

  • Weight-Bearing
  • Transforming Growth Factor beta1
  • Radiography
  • Osteoarthritis, Knee
  • Osteoarthritis, Hip
  • Middle Aged
  • Male
  • Knee Joint
  • Humans
  • Hip Joint