Extreme obesity due to impaired leptin signaling in mice does not cause knee osteoarthritis.

Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't

To test the hypothesis that obesity resulting from deletion of the leptin gene or the leptin receptor gene results in increased knee osteoarthritis (OA), systemic inflammation, and altered subchondral bone morphology.

Full Text

Duke Authors

Cited Authors

  • Griffin, TM; Huebner, JL; Kraus, VB; Guilak, F

Published Date

  • October 2009

Published In

Volume / Issue

  • 60 / 10

Start / End Page

  • 2935 - 2944

PubMed ID

  • 19790050

International Standard Serial Number (ISSN)

  • 0004-3591

Digital Object Identifier (DOI)

  • 10.1002/art.24854


  • eng

Citation Source

  • PubMed