An unconditioned bone marrow transplantation in a child with purine nucleoside phosphorylase deficiency and its unique complication.

Journal Article (Journal Article)

Purine nucleoside phosphorylase deficiency is a rare immunodeficiency syndrome characterized by recurrent infections, neurological dysfunction, and autoimmunity. Early diagnosis and hematopoietic stem cell transplantation may reverse the dismal prognosis in PNP deficiency. This report presents a new PNP deficiency case successfully transplanted without a conditioning regimen from an HLA-identical family donor, who developed a complication of disseminated BCG infection.

Full Text

Duke Authors

Cited Authors

  • Aytekin, C; Yuksek, M; Dogu, F; Yagmurlu, A; Yildiran, A; Fitoz, S; Kologlu, M; Babacan, E; Hershfield, MS; Ikinciogullari, A

Published Date

  • June 2008

Published In

Volume / Issue

  • 12 / 4

Start / End Page

  • 479 - 482

PubMed ID

  • 18208442

Electronic International Standard Serial Number (EISSN)

  • 1399-3046

Digital Object Identifier (DOI)

  • 10.1111/j.1399-3046.2007.00890.x


  • eng

Conference Location

  • Denmark