Uric acid is a danger signal of increasing risk for osteoarthritis through inflammasome activation.

Journal Article

Uric acid (UA) is known to activate the NLRP3 (Nacht, leucine-rich repeat and pyrin domain containing protein 3) inflammasome. When activated, the NLRP3 (also known as NALP3) inflammasome leads to the production of IL-18 and IL-1β. In this cohort of subjects with knee osteoarthritis (OA), synovial fluid uric acid was strongly correlated with synovial fluid IL-18 and IL-1β. Synovial fluid uric acid and IL-18 were strongly and positively associated with OA severity as measured by both radiograph and bone scintigraphy, and synovial fluid IL-1β was associated with OA severity but only by radiograph. Furthermore, synovial fluid IL-18 was associated with a 3-y change in OA severity, on the basis of the radiograph. We conclude that synovial fluid uric acid is a marker of knee OA severity. The correlation of synovial fluid uric acid with the two cytokines (IL-18 and IL-1β) known to be produced by uric acid-activated inflammasomes and the association of synovial fluid IL-18 with OA progression, lend strong support to the potential involvement of the innate immune system in OA pathology and OA progression.

Full Text

Duke Authors

Cited Authors

  • Denoble, AE; Huffman, KM; Stabler, TV; Kelly, SJ; Hershfield, MS; McDaniel, GE; Coleman, RE; Kraus, VB

Published Date

  • February 1, 2011

Published In

Volume / Issue

  • 108 / 5

Start / End Page

  • 2088 - 2093

PubMed ID

  • 21245324

Electronic International Standard Serial Number (EISSN)

  • 1091-6490

Digital Object Identifier (DOI)

  • 10.1073/pnas.1012743108

Language

  • eng

Conference Location

  • United States