Presentation of multicentric Castleman's disease with sicca syndrome, cardiomyopathy, palmar and plantar rash.

Journal Article

Multicentric Castleman's disease (MCD), or multicentric angiofollicular lymph node hyperplasia, is an uncommon lymphoproliferative disorder which typically present with constitutional symptoms, multicentric lymphadenopathy, hepatosplenomegaly, effusions, and ascites. We describe a patient with several novel manifestations of MCD: sicca syndrome, lacrimal and salivary gland enlargement, cardiomyopathy, and palmar and plantar rash. Treatment of MCD with chlorambucil and prednisone was effective in the short term followup of this patient. MCD merits consideration in patients with lymphadenopathy and multisystem disease, including sicca syndrome, heart failure or rash.

Full Text

Duke Authors

Cited Authors

  • Kingsmore, SF; Silva, OE; Hall, BD; Sheldon, EA; Cripe, LD; St Clair, EW

Published Date

  • September 1, 1993

Published In

Volume / Issue

  • 20 / 9

Start / End Page

  • 1588 - 1591

PubMed ID

  • 8164221

International Standard Serial Number (ISSN)

  • 0315-162X

Language

  • eng

Conference Location

  • Canada