Expression of cell-adhesion molecules in the salivary gland microenvironment of Sjögren's syndrome.


Journal Article

OBJECTIVE: The potential role of cell adhesion molecules in the pathogenesis of Sjögren's syndrome (SS) was assessed by examining their expression in salivary gland (SGL) tissue. METHODS: Intercellular adhesion molecule type 1 (ICAM-1), lymphocyte function-associated antigen type 1 (LFA-1), LFA-3, CD2, and CD44 expression were determined using indirect immunofluorescence techniques. RESULTS: In inflamed labial SGL tissue, ICAM-1 expression was evident on infiltrating LFA-1+/CD2+/LFA-3+ mononuclear cells, and to a limited extent on SGL acinar epithelial cells adjacent to sites of intense inflammation. CONCLUSION: In SS, the SGL microenvironment is characterized by only a modest up-regulation of ICAM-1 expression on epithelial cells, despite the presence of T cells bearing an activated phenotype.

Full Text

Duke Authors

Cited Authors

  • St Clair, EW; Angellilo, JC; Singer, KH

Published Date

  • January 1, 1992

Published In

Volume / Issue

  • 35 / 1

Start / End Page

  • 62 - 66

PubMed ID

  • 1370620

Pubmed Central ID

  • 1370620

International Standard Serial Number (ISSN)

  • 0004-3591

Digital Object Identifier (DOI)

  • 10.1002/art.1780350110


  • eng

Conference Location

  • United States