Specificity of autoantibodies for recombinant 60-kd and 52-kd Ro autoantigens.
Journal Article (Journal Article)
OBJECTIVE: To compare patterns of Ro autoantigen recognition in primary Sjögren's syndrome (SS) and systemic lupus erythematosus (SLE). METHODS: Sera were tested by enzyme-linked immunosorbent assay (ELISA) and immunoprecipitation for reactivity with recombinant human 60-kd and 52-kd Ro proteins. RESULTS: SLE and primary SS sera exhibited similar patterns of reactivity with the recombinant 52-kd protein. However, a greater proportion of sera from primary SS patients than from SLE patients did not react with recombinant 60-kd protein in ELISA yet precipitated its translation product in solution-phase assays. CONCLUSION: Disease state can influence recognition of the recombinant 60-kd Ro antigen.
Full Text
Duke Authors
Cited Authors
- St Clair, EW; Burch, JA; Saitta, M
Published Date
- September 1, 1994
Published In
Volume / Issue
- 37 / 9
Start / End Page
- 1373 - 1379
PubMed ID
- 7945502
International Standard Serial Number (ISSN)
- 0004-3591
Digital Object Identifier (DOI)
- 10.1002/art.1780370916
Language
- eng
Conference Location
- United States