Specificity of autoantibodies for recombinant 60-kd and 52-kd Ro autoantigens.

Journal Article (Journal Article)

OBJECTIVE: To compare patterns of Ro autoantigen recognition in primary Sjögren's syndrome (SS) and systemic lupus erythematosus (SLE). METHODS: Sera were tested by enzyme-linked immunosorbent assay (ELISA) and immunoprecipitation for reactivity with recombinant human 60-kd and 52-kd Ro proteins. RESULTS: SLE and primary SS sera exhibited similar patterns of reactivity with the recombinant 52-kd protein. However, a greater proportion of sera from primary SS patients than from SLE patients did not react with recombinant 60-kd protein in ELISA yet precipitated its translation product in solution-phase assays. CONCLUSION: Disease state can influence recognition of the recombinant 60-kd Ro antigen.

Full Text

Duke Authors

Cited Authors

  • St Clair, EW; Burch, JA; Saitta, M

Published Date

  • September 1, 1994

Published In

Volume / Issue

  • 37 / 9

Start / End Page

  • 1373 - 1379

PubMed ID

  • 7945502

International Standard Serial Number (ISSN)

  • 0004-3591

Digital Object Identifier (DOI)

  • 10.1002/art.1780370916


  • eng

Conference Location

  • United States