Anti-La antibodies.

Published

Journal Article (Review)

Anti-La antibodies usually occur in sera with anti-Ro antibodies and represent important serologic markers of Sjögren's syndrome and neonatal lupus erythematosus. In addition to their diagnostic and prognostic significance, anti-La antibodies have proved valuable reagents for molecularly characterizing its antigenic target, which is a 47 kD ribonucleoprotein located in the nucleus and cytoplasm of mammalian cells. The isotype distribution and fine specificity of the anti-La response as well as its associations with HLA-DR and DQ loci suggest that these autoantibodies arise by a T cell-dependent, antigen-driven mechanism. Further insights into the mechanisms of anti-La production in humans may be gained by studying experimental animal models that develop these antibodies spontaneously or through induction by various immunization protocols.

Full Text

Duke Authors

Cited Authors

  • St Clair, EW

Published Date

  • May 1992

Published In

Volume / Issue

  • 18 / 2

Start / End Page

  • 359 - 376

PubMed ID

  • 1626074

Pubmed Central ID

  • 1626074

International Standard Serial Number (ISSN)

  • 0889-857X

Language

  • eng

Conference Location

  • United States