Lack of correlation between serum soluble Fas/APO-1 levels and autoimmune disease.

Journal Article (Journal Article)

OBJECTIVE: To determine whether elevated soluble Fas/APO-1 (sFas/APO-1) levels are associated with either autoimmune disease or evidence of flares in autoimmune disease. METHODS: Thirty-seven serum samples were retrospectively obtained from normal controls and patients with laboratory evidence of autoimmune disease activity. These samples were assayed for sFas/APO-1 levels by an enzyme-linked immunosorbent assay, and hospital medical records were retrospectively reviewed for clinical and laboratory characteristics of the patients. RESULTS: Soluble Fas/APO-1 levels did not correlate with clinical diagnoses or laboratory abnormalities. The mean and range of sFas/APO-1 levels were similar in systemic lupus erythematosus patients (including those with active disease), patients with other autoimmune diseases, and normal controls. CONCLUSION: These data strongly suggest that measurement of sFas/APO-1 levels is unlikely to hold clinical value or play a role in the pathogenesis of autoimmune disease.

Full Text

Duke Authors

Cited Authors

  • Goel, N; Ulrich, DT; St Clair, EW; Fleming, JA; Lynch, DH; Seldin, MF

Published Date

  • December 1995

Published In

Volume / Issue

  • 38 / 12

Start / End Page

  • 1738 - 1743

PubMed ID

  • 8849345

International Standard Serial Number (ISSN)

  • 0004-3591

Digital Object Identifier (DOI)

  • 10.1002/art.1780381206


  • eng

Conference Location

  • United States