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Orchestrating T-cell receptor α gene assembly through changes in chromatin structure and organization.

Publication ,  Journal Article
Shih, H-Y; Hao, B; Krangel, MS
Published in: Immunol Res
April 2011

V(D)J recombination is regulated through changes in chromatin structure that allow recombinase proteins access to recombination signal sequences and through changes in three-dimensional chromatin organization that bring pairs of distant recombination signal sequences into proximity. The Tcra/Tcrd locus is complex and undergoes distinct recombination programs in double negative and double positive thymocytes that lead to the assembly of Tcrd and Tcra genes, respectively. Our studies provide insights into how locus chromatin structure is regulated and how changes in locus chromatin structure can target and then retarget the recombinase to create developmental progressions of recombination events. Our studies also reveal distinct locus conformations in double negative and double positive thymocytes and suggest how these conformations may support the distinct recombination programs in the two compartments.

Duke Scholars

Published In

Immunol Res

DOI

EISSN

1559-0755

Publication Date

April 2011

Volume

49

Issue

1-3

Start / End Page

192 / 201

Location

United States

Related Subject Headings

  • VDJ Recombinases
  • T-Lymphocytes
  • Somatic Hypermutation, Immunoglobulin
  • Signal Transduction
  • Recombination, Genetic
  • Receptors, Antigen, T-Cell, gamma-delta
  • Receptors, Antigen, T-Cell, alpha-beta
  • Immunology
  • Humans
  • Genes, RAG-1
 

Citation

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ICMJE
MLA
NLM
Shih, H.-Y., Hao, B., & Krangel, M. S. (2011). Orchestrating T-cell receptor α gene assembly through changes in chromatin structure and organization. Immunol Res, 49(1–3), 192–201. https://doi.org/10.1007/s12026-010-8181-y
Shih, Han-Yu, Bingtao Hao, and Michael S. Krangel. “Orchestrating T-cell receptor α gene assembly through changes in chromatin structure and organization.Immunol Res 49, no. 1–3 (April 2011): 192–201. https://doi.org/10.1007/s12026-010-8181-y.
Shih H-Y, Hao B, Krangel MS. Orchestrating T-cell receptor α gene assembly through changes in chromatin structure and organization. Immunol Res. 2011 Apr;49(1–3):192–201.
Shih, Han-Yu, et al. “Orchestrating T-cell receptor α gene assembly through changes in chromatin structure and organization.Immunol Res, vol. 49, no. 1–3, Apr. 2011, pp. 192–201. Pubmed, doi:10.1007/s12026-010-8181-y.
Shih H-Y, Hao B, Krangel MS. Orchestrating T-cell receptor α gene assembly through changes in chromatin structure and organization. Immunol Res. 2011 Apr;49(1–3):192–201.
Journal cover image

Published In

Immunol Res

DOI

EISSN

1559-0755

Publication Date

April 2011

Volume

49

Issue

1-3

Start / End Page

192 / 201

Location

United States

Related Subject Headings

  • VDJ Recombinases
  • T-Lymphocytes
  • Somatic Hypermutation, Immunoglobulin
  • Signal Transduction
  • Recombination, Genetic
  • Receptors, Antigen, T-Cell, gamma-delta
  • Receptors, Antigen, T-Cell, alpha-beta
  • Immunology
  • Humans
  • Genes, RAG-1