Regulatory B cells as inhibitors of immune responses and inflammation.

Published

Journal Article (Review)

B cells positively regulate immune responses through antibody production and optimal CD4(+) T-cell activation. However, a specific and functionally important subset of B cells can also negatively regulate immune responses in mouse autoimmunity and inflammation models. The lack or loss of regulatory B cells has been demonstrated by exacerbated symptoms in experimental autoimmune encephalitis, chronic colitis, contact hypersensitivity, collagen-induced arthritis, and non-obese diabetic mouse models. Accumulating evidence suggests that B cells exert their regulatory role through the production of interleukin-10 (IL-10) by either B-1, marginal zone (MZ), or transitional 2-MZ precursor B-cell subsets. We have recently found that IL-10-producing regulatory B cells predominantly localize within a rare CD1d(hi)CD5(+) B-cell subset that shares cell surface markers with both B-1 and MZ B cells. We have labeled this specific subset of regulatory B cells as B10 cells to highlight that these rare CD1d(hi)CD5(+) B cells only produce IL-10 and are responsible for most IL-10 production by B cells and to distinguish them from other regulatory B-cell subsets that may also exist. This review focuses on the recent progress in this field and the exciting opportunities for understanding how this unique B-cell subset influences diverse immune functions.

Full Text

Duke Authors

Cited Authors

  • Bouaziz, J-D; Yanaba, K; Tedder, TF

Published Date

  • August 2008

Published In

Volume / Issue

  • 224 /

Start / End Page

  • 201 - 214

PubMed ID

  • 18759928

Pubmed Central ID

  • 18759928

Electronic International Standard Serial Number (EISSN)

  • 1600-065X

Digital Object Identifier (DOI)

  • 10.1111/j.1600-065X.2008.00661.x

Language

  • eng

Conference Location

  • England