Regulatory B cells as inhibitors of immune responses and inflammation.
Journal Article (Journal Article;Review)
B cells positively regulate immune responses through antibody production and optimal CD4(+) T-cell activation. However, a specific and functionally important subset of B cells can also negatively regulate immune responses in mouse autoimmunity and inflammation models. The lack or loss of regulatory B cells has been demonstrated by exacerbated symptoms in experimental autoimmune encephalitis, chronic colitis, contact hypersensitivity, collagen-induced arthritis, and non-obese diabetic mouse models. Accumulating evidence suggests that B cells exert their regulatory role through the production of interleukin-10 (IL-10) by either B-1, marginal zone (MZ), or transitional 2-MZ precursor B-cell subsets. We have recently found that IL-10-producing regulatory B cells predominantly localize within a rare CD1d(hi)CD5(+) B-cell subset that shares cell surface markers with both B-1 and MZ B cells. We have labeled this specific subset of regulatory B cells as B10 cells to highlight that these rare CD1d(hi)CD5(+) B cells only produce IL-10 and are responsible for most IL-10 production by B cells and to distinguish them from other regulatory B-cell subsets that may also exist. This review focuses on the recent progress in this field and the exciting opportunities for understanding how this unique B-cell subset influences diverse immune functions.
Full Text
Duke Authors
Cited Authors
- Bouaziz, J-D; Yanaba, K; Tedder, TF
Published Date
- August 2008
Published In
Volume / Issue
- 224 /
Start / End Page
- 201 - 214
PubMed ID
- 18759928
Electronic International Standard Serial Number (EISSN)
- 1600-065X
Digital Object Identifier (DOI)
- 10.1111/j.1600-065X.2008.00661.x
Language
- eng
Conference Location
- England