Regulatory B cells as inhibitors of immune responses and inflammation.
B cells positively regulate immune responses through antibody production and optimal CD4(+) T-cell activation. However, a specific and functionally important subset of B cells can also negatively regulate immune responses in mouse autoimmunity and inflammation models. The lack or loss of regulatory B cells has been demonstrated by exacerbated symptoms in experimental autoimmune encephalitis, chronic colitis, contact hypersensitivity, collagen-induced arthritis, and non-obese diabetic mouse models. Accumulating evidence suggests that B cells exert their regulatory role through the production of interleukin-10 (IL-10) by either B-1, marginal zone (MZ), or transitional 2-MZ precursor B-cell subsets. We have recently found that IL-10-producing regulatory B cells predominantly localize within a rare CD1d(hi)CD5(+) B-cell subset that shares cell surface markers with both B-1 and MZ B cells. We have labeled this specific subset of regulatory B cells as B10 cells to highlight that these rare CD1d(hi)CD5(+) B cells only produce IL-10 and are responsible for most IL-10 production by B cells and to distinguish them from other regulatory B-cell subsets that may also exist. This review focuses on the recent progress in this field and the exciting opportunities for understanding how this unique B-cell subset influences diverse immune functions.
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Related Subject Headings
- Mice
- Lymphocyte Activation
- Interleukin-10
- Inflammation
- Immunology
- Immunologic Factors
- Disease Models, Animal
- CD5 Antigens
- CD4-Positive T-Lymphocytes
- B-Lymphocytes
Citation
Published In
DOI
EISSN
ISSN
Publication Date
Volume
Start / End Page
Related Subject Headings
- Mice
- Lymphocyte Activation
- Interleukin-10
- Inflammation
- Immunology
- Immunologic Factors
- Disease Models, Animal
- CD5 Antigens
- CD4-Positive T-Lymphocytes
- B-Lymphocytes