B cells contribute to ischemia/reperfusion-mediated tissue injury.

Journal Article (Journal Article)

Multiple elements are known to participate in ischemia/reperfusion (I/R)-mediated tissue injury. Amongst them, B cells have been shown to contribute by the production of antibodies that bind to ischemic cells and fix complement. It is currently unknown whether B cells participate through antibody-independent mechanisms in the pathogenesis of I/R. In a mesenteric I/R model we found that B cells infiltrate the injured intestine of normal and autoimmune mice 2h after reperfusion is established. B cell depletion protected mice from the development of I/R-mediated intestinal damage. The protection conferred by B cell depletion was significantly greater in MRL/lpr mice. Finally, we show that ischemic tissue expressed the B cell-attractant CXCL13 and infiltrating B cells expressed the corresponding receptor CXCR5. Our data grant B cells an antibody-independent role in the pathogenesis of intestinal I/R and suggest that B cells accumulate in the injured tissue in response to the chemokine CXCL13.

Full Text

Duke Authors

Cited Authors

  • Chen, J; Crispín, JC; Tedder, TF; Dalle Lucca, J; Tsokos, GC

Published Date

  • 2009

Published In

Volume / Issue

  • 32 / 3-4

Start / End Page

  • 195 - 200

PubMed ID

  • 19342197

Pubmed Central ID

  • PMC3734555

Electronic International Standard Serial Number (EISSN)

  • 1095-9157

Digital Object Identifier (DOI)

  • 10.1016/j.jaut.2009.02.021


  • eng

Conference Location

  • England