B-lymphocyte effector functions in health and disease.

Journal Article (Review)

B-lymphocytes have traditionally been thought to contribute to immunity and autoimmune disease through terminal differentiation into plasma cells that secrete antibody. However, studies in mice and recent clinical studies have demonstrated that genetically altered B-cell function and B-cell-targeted therapies can significantly affect autoimmune diseases that were predominantly thought to be T-cell-mediated. B-cell depletion in mouse models of disease has also led to the identification of alternative B-cell effector functions that regulate normal immune responses and autoimmune disease. This review highlights multiple B-cell effector mechanisms, including the promotion of cellular immunity, the negative regulation of immune responses, and the production of pathogenic antibodies.

Full Text

Duke Authors

Cited Authors

  • DiLillo, DJ; Horikawa, M; Tedder, TF

Published Date

  • April 2011

Published In

Volume / Issue

  • 49 / 1-3

Start / End Page

  • 281 - 292

PubMed ID

  • 21125343

Electronic International Standard Serial Number (EISSN)

  • 1559-0755

Digital Object Identifier (DOI)

  • 10.1007/s12026-010-8189-3

Language

  • eng

Conference Location

  • United States