The Treatment for Adolescents with Depression Study (TADS): Demographic and clinical characteristics

Journal Article

Objective: The Treatment for Adolescents With Depression Study is a multicenter, randomized clinical trial sponsored by the NIMH. This study is designed to evaluate the short- and long-term effectiveness of four treatments for adolescents with major depressive disorder: fluoxetine, cognitive-behavioral therapy, their combination, and, acutely, pill placebo. This report describes the demographic and clinical characteristics of the sample and addresses external validity. Method: Participants are 439 adolescents, aged 12-17 years inclusively, with a primary DSM-IV diagnosis of current major depressive disorder. Baseline data are summarized and compared with those from national samples and previous trials. Results: The sample composition is 54.4% girls, 73.8% white, 12.5% African American, and 8.9% Hispanic. The mean Child Depression Rating Scale-Revised total score is 60.1 (SD = 10.4, range 45-98) with 86.0% experiencing their first major depressive episode. The most common concurrent diagnoses are generalized anxiety disorder (15.3%), attention-deficit/hyperactivity disorder (13.7%), oppositional defiant disorder (13.2%), social phobia (10.7%), and dysthymia (10.5%). Demographic results are consistent with data from national samples and large psychopharmacology trials involving depressed adolescents. Conclusions: The Treatment for Adolescents With Depression Study provides a large, diverse, and representative sample of depressed adolescents that highlights the complexity of major depressive disorder in adolescents and provides a rich source for explicating the effects of moderator and mediator variables on baseline psychopathology and treatment outcome.

Full Text

Duke Authors

Cited Authors

  • March, J; Silva, S; Petrycki, S; Curry, J; Wells, K; Fairbank, J; Burns, B; Domino, M; McNulty, S; Vitiello, B; Severe, J; Casat, C; Kolker, J; Riedal, K; Goldman, M; Feeny, N; Findling, R; Stull, S; McNamara, N; Weller, E; Robins, M; Weller, R; Jessani, N; Waslick, B; Sweeney, M; Kandel, R; Schoenholz, D; Walkup, J; Ginsburg, G; Kastelic, E; Koo, H; Kratochvil, C; May, D; LaGrone, R; Harrington, M; Albano, AM; Hirsch, G; Knibbs, T; Capili, E; Reinecke, M; Leventhal, B; Nageotte, C; Rogers, G et al.

Published Date

  • 2005

Published In

Volume / Issue

  • 44 / 1

Start / End Page

  • 28 - 40

PubMed ID

  • 15608541

International Standard Serial Number (ISSN)

  • 0890-8567

Digital Object Identifier (DOI)

  • 10.1097/01.chi.0000145807.09027.82