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CSF, plasma viral load and HIV associated dementia.

Publication ,  Journal Article
Robertson, K; Fiscus, S; Kapoor, C; Robertson, W; Schneider, G; Shepard, R; Howe, L; Silva, S; Hall, C
Published in: Journal of neurovirology
February 1998

Plasma viral burden has proven valuable in predicting the future course of systemic HIV related disease and the response to treatment. It is not known whether plasma or cerebrospinal fluid (CSF) viral burden can be used to predict onset of or response to treatment of nervous system disease. We propose a model of viral load mediated neurotoxicity underlying peripheral and central HIV associated neurological disease. The objective of this preliminary study was to assess the relationship of HIV associated neurological disease to quantitative viral load in plasma and CSF. 47 subjects (HIV- = 10, HIV+ = 37) participated in the study. Plasma and CSF samples were collected within a 3 h window. RT-PCR (Roche Amplicor Monitor) was utilized to assess HIV-1 RNA viral load in both plasma and cell free (centrifuged) CSF. Subjects underwent concurrent comprehensive neurological and neuropsychological evaluations. In general, systemic viral load, as measured in plasma, was greater than that found in cell free CSF. Cell free CSF HIV RNA viral load was significantly correlated with neurological dysfunction, whereas plasma viral load was not. The sole subject with an elevated CSF viral load (> 5 Log 10), had HIV associated dementia (HAD) on clinical examination.

Duke Scholars

Published In

Journal of neurovirology

DOI

EISSN

1538-2443

ISSN

1355-0284

Publication Date

February 1998

Volume

4

Issue

1

Start / End Page

90 / 94

Related Subject Headings

  • Virology
  • Viral Load
  • RNA, Viral
  • Polymerase Chain Reaction
  • Middle Aged
  • Male
  • Humans
  • HIV-1
  • Female
  • Child
 

Citation

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Robertson, K., Fiscus, S., Kapoor, C., Robertson, W., Schneider, G., Shepard, R., … Hall, C. (1998). CSF, plasma viral load and HIV associated dementia. Journal of Neurovirology, 4(1), 90–94. https://doi.org/10.3109/13550289809113485
Robertson, K., S. Fiscus, C. Kapoor, W. Robertson, G. Schneider, R. Shepard, L. Howe, S. Silva, and C. Hall. “CSF, plasma viral load and HIV associated dementia.Journal of Neurovirology 4, no. 1 (February 1998): 90–94. https://doi.org/10.3109/13550289809113485.
Robertson K, Fiscus S, Kapoor C, Robertson W, Schneider G, Shepard R, et al. CSF, plasma viral load and HIV associated dementia. Journal of neurovirology. 1998 Feb;4(1):90–4.
Robertson, K., et al. “CSF, plasma viral load and HIV associated dementia.Journal of Neurovirology, vol. 4, no. 1, Feb. 1998, pp. 90–94. Epmc, doi:10.3109/13550289809113485.
Robertson K, Fiscus S, Kapoor C, Robertson W, Schneider G, Shepard R, Howe L, Silva S, Hall C. CSF, plasma viral load and HIV associated dementia. Journal of neurovirology. 1998 Feb;4(1):90–94.
Journal cover image

Published In

Journal of neurovirology

DOI

EISSN

1538-2443

ISSN

1355-0284

Publication Date

February 1998

Volume

4

Issue

1

Start / End Page

90 / 94

Related Subject Headings

  • Virology
  • Viral Load
  • RNA, Viral
  • Polymerase Chain Reaction
  • Middle Aged
  • Male
  • Humans
  • HIV-1
  • Female
  • Child