Although numerous supportive therapies are available to challenge human immunodeficiency virus (HIV) disease and acquired immunodeficiency syndrome (AIDS), no cure exists. Those with HIV disease and its sequelae must confront the reality of living with a complex, chronic illness. When addressing the many challenges associated with HIV disease and AIDS, individuals may experience issues associated with spirituality. The article synthesizes the concept of spirituality and identifies the possible issues associated with spirituality for individuals living with HIV disease and AIDS. Additionally, nursing strategies based on Parse's theory of human becoming are proposed.