Xenotransplantation of baboon bone marrow cells: a historical review of the protocols as a possible treatment modality for HIV/AIDS.

Journal Article (Review;Journal Article)

Despite great advances and a significant understanding of HIV pathogenesis, no curative treatment modality currently exists. Since baboon bone marrow cells (BBMC) are believed to be resistant to the human immunodeficiency virus, researchers have recently transplanted BBMC into two patients with AIDS, a process known as xenotransplantation. The purpose of this paper is to provide a comparative analysis of human and baboon hematopoiesis, followed by a review of the pathophysiologic effects of the HIV on the human hematologic and immune systems. The two protocols implemented since 1994 are discussed, including an overview of the potential risks and benefits and implications for nursing practice.

Full Text

Duke Authors

Cited Authors

  • Relf, MV

Published Date

  • September 1996

Published In

Volume / Issue

  • 7 / 5

Start / End Page

  • 27 - 35

PubMed ID

  • 8906734

Electronic International Standard Serial Number (EISSN)

  • 1552-6917

International Standard Serial Number (ISSN)

  • 1055-3290

Digital Object Identifier (DOI)

  • 10.1016/s1055-3290(96)80043-4


  • eng