Gout, hyperuricemia, and the risk of cardiovascular disease: cause and effect?

Journal Article (Journal Article;Review)

Gout and hyperuricemia have long been suspected to be risk factors for cardiovascular disease. However, studies have frequently failed to distinguish whether these entities have an independent effect on cardiovascular risk or serve as markers for other risk factors. In vitro and animal studies suggest that uric acid is a biologically active compound that can increase inflammatory mediators known to lead to vascular damage. In contrast, uric acid also has potentially protective effects as a strong antioxidant, approaching the potency of vitamin C. Large clinical trials demonstrate a consistent relationship between elevated serum uric acid and a variety of cardiovascular diseases, although the strength of association varies greatly. We review the evidence for and against an independent role for hyperuricemia and/or gout in cardiovascular pathology.

Full Text

Duke Authors

Cited Authors

  • Shah, A; Keenan, RT

Published Date

  • April 2010

Published In

Volume / Issue

  • 12 / 2

Start / End Page

  • 118 - 124

PubMed ID

  • 20425020

Electronic International Standard Serial Number (EISSN)

  • 1534-6307

Digital Object Identifier (DOI)

  • 10.1007/s11926-010-0084-3


  • eng

Conference Location

  • United States