Current use for old antibacterial agents: polymyxins, rifamycins, and aminoglycosides.


Journal Article (Review)

This article reviews three classes of antibacterial agents that are uncommonly used in bacterial infections and therefore can be thought of as special-use agents. The polymyxins are reserved for gram-negative bacilli that are resistant to virtually all other classes of drugs. Rifampin is used therapeutically, occasionally as a companion drug in treatment of refractory gram-positive coccal infections, especially those involving foreign bodies. Rifaximin is a new rifamycin that is a strict enteric antibiotic approved for treatment of traveler's diarrhea and is showing promise as a possible agent for refractory Clostridium difficile infections. The aminoglycosides are used mainly as companion drugs for the treatment of resistant gram-negative bacillary infections and for gram-positive coccal endocarditis.

Full Text

Cited Authors

  • Chen, LF; Kaye, D

Published Date

  • December 2009

Published In

Volume / Issue

  • 23 / 4

Start / End Page

  • 1053 - x

PubMed ID

  • 19909897

Pubmed Central ID

  • 19909897

Electronic International Standard Serial Number (EISSN)

  • 1557-9824

Digital Object Identifier (DOI)

  • 10.1016/j.idc.2009.06.004


  • eng

Conference Location

  • United States