Geographical variability of alpha-1-antitrypsin alleles in China: a study on six Chinese populations.


Journal Article

Alpha-1-antitrypsin phenotypes of six Chinese Han populations (20 degrees-45 degrees N. latitude) were determined. The frequency of allele M2 increases from North to South China. The north-south change of M2 appears to be mainly at the expense of alleles M1 and M3. Geographical variability of other variants was also observed. In the northern populations, the most common variants are M4 and Etokyo; in the southern populations, Pweishi, a variant which can not be distinguished electrophoretically from Pyasugi. These results form a distribution pattern of alpha-1-antitrypsin alleles in China.

Full Text

Cited Authors

  • Ying, QL; Zhang, ML; Liang, CC; Liu, XP; Huang, YW; Wang, RX; Zhang, NJ; Chen, LC; Chen, LF; Yu, NC

Published Date

  • January 1, 1985

Published In

Volume / Issue

  • 69 / 2

Start / End Page

  • 184 - 187

PubMed ID

  • 3871725

Pubmed Central ID

  • 3871725

Electronic International Standard Serial Number (EISSN)

  • 1432-1203

International Standard Serial Number (ISSN)

  • 0340-6717

Digital Object Identifier (DOI)

  • 10.1007/bf00293295


  • eng