Toll-like receptors in the pathogenesis of human disease.

Journal Article (Journal Article;Review)

Members of the Toll-like receptor (TLR) family are key regulators of both innate and adaptive immune responses. The function of TLRs in various human diseases has been investigated by comparison of the incidence of disease among people having different polymorphisms in genes that participate in TLR signaling. These studies have shown that TLR function affects several diseases, including sepsis, immunodeficiencies, atherosclerosis and asthma. As this body of data grows, it will provide new insights into disease pathogenesis as well as valuable information on the merits of various therapeutic options.

Full Text

Duke Authors

Cited Authors

  • Cook, DN; Pisetsky, DS; Schwartz, DA

Published Date

  • October 2004

Published In

Volume / Issue

  • 5 / 10

Start / End Page

  • 975 - 979

PubMed ID

  • 15454920

International Standard Serial Number (ISSN)

  • 1529-2908

Digital Object Identifier (DOI)

  • 10.1038/ni1116


  • eng

Conference Location

  • United States