Skip to main content

Toll-like receptors in the pathogenesis of human disease.

Publication ,  Journal Article
Cook, DN; Pisetsky, DS; Schwartz, DA
Published in: Nat Immunol
October 2004

Members of the Toll-like receptor (TLR) family are key regulators of both innate and adaptive immune responses. The function of TLRs in various human diseases has been investigated by comparison of the incidence of disease among people having different polymorphisms in genes that participate in TLR signaling. These studies have shown that TLR function affects several diseases, including sepsis, immunodeficiencies, atherosclerosis and asthma. As this body of data grows, it will provide new insights into disease pathogenesis as well as valuable information on the merits of various therapeutic options.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

Nat Immunol

DOI

ISSN

1529-2908

Publication Date

October 2004

Volume

5

Issue

10

Start / End Page

975 / 979

Location

United States

Related Subject Headings

  • Toll-Like Receptors
  • Sepsis
  • Receptors, Cell Surface
  • Protein Serine-Threonine Kinases
  • Membrane Glycoproteins
  • Immunology
  • Immune Tolerance
  • I-kappa B Kinase
  • Humans
  • Bacterial Infections
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Cook, D. N., Pisetsky, D. S., & Schwartz, D. A. (2004). Toll-like receptors in the pathogenesis of human disease. Nat Immunol, 5(10), 975–979. https://doi.org/10.1038/ni1116
Cook, Donald N., David S. Pisetsky, and David A. Schwartz. “Toll-like receptors in the pathogenesis of human disease.Nat Immunol 5, no. 10 (October 2004): 975–79. https://doi.org/10.1038/ni1116.
Cook DN, Pisetsky DS, Schwartz DA. Toll-like receptors in the pathogenesis of human disease. Nat Immunol. 2004 Oct;5(10):975–9.
Cook, Donald N., et al. “Toll-like receptors in the pathogenesis of human disease.Nat Immunol, vol. 5, no. 10, Oct. 2004, pp. 975–79. Pubmed, doi:10.1038/ni1116.
Cook DN, Pisetsky DS, Schwartz DA. Toll-like receptors in the pathogenesis of human disease. Nat Immunol. 2004 Oct;5(10):975–979.

Published In

Nat Immunol

DOI

ISSN

1529-2908

Publication Date

October 2004

Volume

5

Issue

10

Start / End Page

975 / 979

Location

United States

Related Subject Headings

  • Toll-Like Receptors
  • Sepsis
  • Receptors, Cell Surface
  • Protein Serine-Threonine Kinases
  • Membrane Glycoproteins
  • Immunology
  • Immune Tolerance
  • I-kappa B Kinase
  • Humans
  • Bacterial Infections