Toll-like receptors in the pathogenesis of human disease.
Publication
, Journal Article
Cook, DN; Pisetsky, DS; Schwartz, DA
Published in: Nat Immunol
October 2004
Members of the Toll-like receptor (TLR) family are key regulators of both innate and adaptive immune responses. The function of TLRs in various human diseases has been investigated by comparison of the incidence of disease among people having different polymorphisms in genes that participate in TLR signaling. These studies have shown that TLR function affects several diseases, including sepsis, immunodeficiencies, atherosclerosis and asthma. As this body of data grows, it will provide new insights into disease pathogenesis as well as valuable information on the merits of various therapeutic options.
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Published In
Nat Immunol
DOI
ISSN
1529-2908
Publication Date
October 2004
Volume
5
Issue
10
Start / End Page
975 / 979
Location
United States
Related Subject Headings
- Toll-Like Receptors
- Sepsis
- Receptors, Cell Surface
- Protein Serine-Threonine Kinases
- Membrane Glycoproteins
- Immunology
- Immune Tolerance
- I-kappa B Kinase
- Humans
- Bacterial Infections
Citation
APA
Chicago
ICMJE
MLA
NLM
Cook, D. N., Pisetsky, D. S., & Schwartz, D. A. (2004). Toll-like receptors in the pathogenesis of human disease. Nat Immunol, 5(10), 975–979. https://doi.org/10.1038/ni1116
Cook, Donald N., David S. Pisetsky, and David A. Schwartz. “Toll-like receptors in the pathogenesis of human disease.” Nat Immunol 5, no. 10 (October 2004): 975–79. https://doi.org/10.1038/ni1116.
Cook DN, Pisetsky DS, Schwartz DA. Toll-like receptors in the pathogenesis of human disease. Nat Immunol. 2004 Oct;5(10):975–9.
Cook, Donald N., et al. “Toll-like receptors in the pathogenesis of human disease.” Nat Immunol, vol. 5, no. 10, Oct. 2004, pp. 975–79. Pubmed, doi:10.1038/ni1116.
Cook DN, Pisetsky DS, Schwartz DA. Toll-like receptors in the pathogenesis of human disease. Nat Immunol. 2004 Oct;5(10):975–979.
Published In
Nat Immunol
DOI
ISSN
1529-2908
Publication Date
October 2004
Volume
5
Issue
10
Start / End Page
975 / 979
Location
United States
Related Subject Headings
- Toll-Like Receptors
- Sepsis
- Receptors, Cell Surface
- Protein Serine-Threonine Kinases
- Membrane Glycoproteins
- Immunology
- Immune Tolerance
- I-kappa B Kinase
- Humans
- Bacterial Infections