The role of microparticles in the pathogenesis of rheumatic diseases.

Published

Journal Article (Review)

Microparticles (MPs) are small membrane-bound vesicles that are emerging as important elements in the pathogenesis of rheumatic diseases owing to their pleiotropic effects on thrombosis, vascular reactivity, angiogenesis and inflammation. Released from cells during activation and apoptosis, MPs carry proteins, lipids and nucleic acids, and serve as platforms for enzymatic processes in thrombosis. Furthermore, MPs can transfer cytokines, receptors, RNA and DNA to modulate the properties of target cells. As MPs appear in the blood in increased numbers during rheumatic disease, they represent novel biomarkers that can be used to assess events in otherwise inaccessible tissues. Future research will define further the pathogenetic role of MPs and explore therapeutic strategies to block their release or signaling properties.

Full Text

Duke Authors

Cited Authors

  • Beyer, C; Pisetsky, DS

Published Date

  • January 2010

Published In

Volume / Issue

  • 6 / 1

Start / End Page

  • 21 - 29

PubMed ID

  • 19949432

Pubmed Central ID

  • 19949432

Electronic International Standard Serial Number (EISSN)

  • 1759-4804

Digital Object Identifier (DOI)

  • 10.1038/nrrheum.2009.229

Language

  • eng

Conference Location

  • United States