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Lymphocytic lymphoma and systemic lupus erythematosus: their coexistence with antibody to the Sm antigen.

Publication ,  Journal Article
McCarty, GA; Rice, JR; Fetter, BF; Pisetsky, DS
Published in: Arch Pathol Lab Med
April 1982

The serologic and clinical features of a 32-year-old women with coexistent systemic lupus erythematosus and lymphoma were studied. A cervical node biopsy specimen demonstrated nodular, poorly differentiated lymphocytic lymphoma; subsequent development of polyarthralgias prompted evaluation for connective-tissue disease, and a high titer of antinuclear antibody was found. Immunochemical studies proved that this antibody was directed to the Sm antigen, a serologic finding highly specific for systemic lupus erythematosus. This antibody has been maintained throughout the course of the patient's disease, characterized by persistent lymphadenopathy, pleuropericarditis, arthritis, hypocomplementemia, hyperglobulinemia, and a slight elevation of titers of anti-DNA antibody. The course of the lymphoproliferative disorder has been consistent with that of an indolent non-Hodgkin's lymphoma. In sera from other patients with lymphoproliferative disorders, anti-Sm antibody was not found. These findings emphasize the importance of establishing the antigenic specificity of antinuclear antibodies detected in the sera of patients with neoplasia.

Duke Scholars

Published In

Arch Pathol Lab Med

ISSN

0003-9985

Publication Date

April 1982

Volume

106

Issue

4

Start / End Page

196 / 199

Location

United States

Related Subject Headings

  • Ribonucleoproteins
  • Pathology
  • Lymphoma, Non-Hodgkin
  • Lymph Nodes
  • Lupus Erythematosus, Systemic
  • Humans
  • Fluorescent Antibody Technique
  • Female
  • Epitopes
  • Antibodies, Neoplasm
 

Citation

APA
Chicago
ICMJE
MLA
NLM
McCarty, G. A., Rice, J. R., Fetter, B. F., & Pisetsky, D. S. (1982). Lymphocytic lymphoma and systemic lupus erythematosus: their coexistence with antibody to the Sm antigen. Arch Pathol Lab Med, 106(4), 196–199.
McCarty, G. A., J. R. Rice, B. F. Fetter, and D. S. Pisetsky. “Lymphocytic lymphoma and systemic lupus erythematosus: their coexistence with antibody to the Sm antigen.Arch Pathol Lab Med 106, no. 4 (April 1982): 196–99.
McCarty GA, Rice JR, Fetter BF, Pisetsky DS. Lymphocytic lymphoma and systemic lupus erythematosus: their coexistence with antibody to the Sm antigen. Arch Pathol Lab Med. 1982 Apr;106(4):196–9.
McCarty, G. A., et al. “Lymphocytic lymphoma and systemic lupus erythematosus: their coexistence with antibody to the Sm antigen.Arch Pathol Lab Med, vol. 106, no. 4, Apr. 1982, pp. 196–99.
McCarty GA, Rice JR, Fetter BF, Pisetsky DS. Lymphocytic lymphoma and systemic lupus erythematosus: their coexistence with antibody to the Sm antigen. Arch Pathol Lab Med. 1982 Apr;106(4):196–199.

Published In

Arch Pathol Lab Med

ISSN

0003-9985

Publication Date

April 1982

Volume

106

Issue

4

Start / End Page

196 / 199

Location

United States

Related Subject Headings

  • Ribonucleoproteins
  • Pathology
  • Lymphoma, Non-Hodgkin
  • Lymph Nodes
  • Lupus Erythematosus, Systemic
  • Humans
  • Fluorescent Antibody Technique
  • Female
  • Epitopes
  • Antibodies, Neoplasm