Lymphocytic lymphoma and systemic lupus erythematosus: their coexistence with antibody to the Sm antigen.

Published

Journal Article

The serologic and clinical features of a 32-year-old women with coexistent systemic lupus erythematosus and lymphoma were studied. A cervical node biopsy specimen demonstrated nodular, poorly differentiated lymphocytic lymphoma; subsequent development of polyarthralgias prompted evaluation for connective-tissue disease, and a high titer of antinuclear antibody was found. Immunochemical studies proved that this antibody was directed to the Sm antigen, a serologic finding highly specific for systemic lupus erythematosus. This antibody has been maintained throughout the course of the patient's disease, characterized by persistent lymphadenopathy, pleuropericarditis, arthritis, hypocomplementemia, hyperglobulinemia, and a slight elevation of titers of anti-DNA antibody. The course of the lymphoproliferative disorder has been consistent with that of an indolent non-Hodgkin's lymphoma. In sera from other patients with lymphoproliferative disorders, anti-Sm antibody was not found. These findings emphasize the importance of establishing the antigenic specificity of antinuclear antibodies detected in the sera of patients with neoplasia.

Full Text

Duke Authors

Cited Authors

  • McCarty, GA; Rice, JR; Fetter, BF; Pisetsky, DS

Published Date

  • April 1982

Published In

Volume / Issue

  • 106 / 4

Start / End Page

  • 196 - 199

PubMed ID

  • 6175291

Pubmed Central ID

  • 6175291

International Standard Serial Number (ISSN)

  • 0003-9985

Language

  • eng

Conference Location

  • United States