Ir genes of different high responder haplotypes for staphylococcal nuclease are not allelic.

Published

Journal Article

The Ir gene controlling high responsiveness to staphylococcal nuclease in the H-2d haplotype has been mapped to the I-A subregion, in contrast to that in the H-2k and H-2a haplotypes, which maps in the I-B subregion. The nonallelic high responder genes also confer differences in fine specificity on the antibodies produced. This nonallelism of Ir genes for the same antigen in different haplotypes is consistent with Ir gene mechanisms involving associative recognition of antigen plus Ia by T lymphocytes. It further suggests that products of different subregions can perform the same function.

Full Text

Duke Authors

Cited Authors

  • Berzofsky, JA; Pisetsky, DS; Killion, DJ; Hicks, G; Sachs, DH

Published Date

  • December 1, 1981

Published In

Volume / Issue

  • 127 / 6

Start / End Page

  • 2453 - 2455

PubMed ID

  • 6795275

Pubmed Central ID

  • 6795275

International Standard Serial Number (ISSN)

  • 0022-1767

Language

  • eng

Conference Location

  • United States