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Independent expression of autoantibodies in systemic lupus erythematosus.

Publication ,  Journal Article
McCarty, GA; Rice, JR; Bembe, ML; Pisetsky, DS
Published in: J Rheumatol
1982

Antibodies to components of the cell nucleus have been viewed as specific serological markers of systemic lupus erythematosus (SLE). To determine whether these autoantibodies exhibit common regulation of their expression, antibody levels have been quantitatively assessed in serial samples from patients producing at least 2 different antibody specificities. In a comparison of the peak antibody levels as a measure of immune responsiveness, the magnitude of the antiDNA response varied independently of either the antiSm or the antiRNP responses. Serial analysis with selected patients demonstrated that antiDNA levels fluctuated according to a pattern related to disease activity. In the same patients, however, antiSm and antiRNP antibodies showed little variation in level, with no consistent relationship to disease activity. Furthermore, following therapy, antiDNA levels fell while neither antiSm nor antiRNP levels showed significant alteration. These results suggest that in SLE, autoantibodies may arise from distinct immunoregulatory disturbances, each characterized by a unique relationship to disease activity and response to therapy.

Duke Scholars

Published In

J Rheumatol

ISSN

0315-162X

Publication Date

1982

Volume

9

Issue

5

Start / End Page

691 / 695

Location

Canada

Related Subject Headings

  • snRNP Core Proteins
  • Ribonucleoproteins, Small Nuclear
  • Ribonucleoproteins
  • Lupus Erythematosus, Systemic
  • Humans
  • Autoantigens
  • Autoantibodies
  • Arthritis & Rheumatology
  • Antigens
  • Antibody Specificity
 

Citation

APA
Chicago
ICMJE
MLA
NLM
McCarty, G. A., Rice, J. R., Bembe, M. L., & Pisetsky, D. S. (1982). Independent expression of autoantibodies in systemic lupus erythematosus. J Rheumatol, 9(5), 691–695.
McCarty, G. A., J. R. Rice, M. L. Bembe, and D. S. Pisetsky. “Independent expression of autoantibodies in systemic lupus erythematosus.J Rheumatol 9, no. 5 (1982): 691–95.
McCarty GA, Rice JR, Bembe ML, Pisetsky DS. Independent expression of autoantibodies in systemic lupus erythematosus. J Rheumatol. 1982;9(5):691–5.
McCarty, G. A., et al. “Independent expression of autoantibodies in systemic lupus erythematosus.J Rheumatol, vol. 9, no. 5, 1982, pp. 691–95.
McCarty GA, Rice JR, Bembe ML, Pisetsky DS. Independent expression of autoantibodies in systemic lupus erythematosus. J Rheumatol. 1982;9(5):691–695.

Published In

J Rheumatol

ISSN

0315-162X

Publication Date

1982

Volume

9

Issue

5

Start / End Page

691 / 695

Location

Canada

Related Subject Headings

  • snRNP Core Proteins
  • Ribonucleoproteins, Small Nuclear
  • Ribonucleoproteins
  • Lupus Erythematosus, Systemic
  • Humans
  • Autoantigens
  • Autoantibodies
  • Arthritis & Rheumatology
  • Antigens
  • Antibody Specificity