Stimulation of murine lymphocyte proliferation by a phosphorothioate oligonucleotide with antisense activity for herpes simplex virus.
Publication
, Journal Article
Pisetsky, DS; Reich, CF
Published in: Life Sci
1994
To investigate further the immunological properties of nucleic acids, the mitogenicity of a phosphorothioate oligonucleotide (S-oligo 1082) with antisense activity for herpes simplex virus was tested. This compound stimulated proliferation and antibody production by murine lymphocytes in in vitro cultures. Proliferation was dose-dependent and unaffected by T cell depletion. Furthermore, inclusion of a non-mitogenic DNA in the medium did not block stimulation. Since 1082 does not have homology to a known gene involved in lymphocyte activation, these observations suggest that S-oligo antisense compounds may display non-specific activating effects, at least on murine B cells.
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Published In
Life Sci
DOI
ISSN
0024-3205
Publication Date
1994
Volume
54
Issue
2
Start / End Page
101 / 107
Location
Netherlands
Related Subject Headings
- Thionucleotides
- Simplexvirus
- Pharmacology & Pharmacy
- Oligonucleotides, Antisense
- Oligodeoxyribonucleotides, Antisense
- Molecular Sequence Data
- Mice, Inbred BALB C
- Mice
- Male
- Lymphocyte Activation
Citation
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Chicago
ICMJE
MLA
NLM
Pisetsky, D. S., & Reich, C. F. (1994). Stimulation of murine lymphocyte proliferation by a phosphorothioate oligonucleotide with antisense activity for herpes simplex virus. Life Sci, 54(2), 101–107. https://doi.org/10.1016/0024-3205(94)00780-2
Pisetsky, D. S., and C. F. Reich. “Stimulation of murine lymphocyte proliferation by a phosphorothioate oligonucleotide with antisense activity for herpes simplex virus.” Life Sci 54, no. 2 (1994): 101–7. https://doi.org/10.1016/0024-3205(94)00780-2.
Pisetsky DS, Reich CF. Stimulation of murine lymphocyte proliferation by a phosphorothioate oligonucleotide with antisense activity for herpes simplex virus. Life Sci. 1994;54(2):101–7.
Pisetsky, D. S., and C. F. Reich. “Stimulation of murine lymphocyte proliferation by a phosphorothioate oligonucleotide with antisense activity for herpes simplex virus.” Life Sci, vol. 54, no. 2, 1994, pp. 101–07. Pubmed, doi:10.1016/0024-3205(94)00780-2.
Pisetsky DS, Reich CF. Stimulation of murine lymphocyte proliferation by a phosphorothioate oligonucleotide with antisense activity for herpes simplex virus. Life Sci. 1994;54(2):101–107.
Published In
Life Sci
DOI
ISSN
0024-3205
Publication Date
1994
Volume
54
Issue
2
Start / End Page
101 / 107
Location
Netherlands
Related Subject Headings
- Thionucleotides
- Simplexvirus
- Pharmacology & Pharmacy
- Oligonucleotides, Antisense
- Oligodeoxyribonucleotides, Antisense
- Molecular Sequence Data
- Mice, Inbred BALB C
- Mice
- Male
- Lymphocyte Activation