Mechanisms of anti-DNA production in human and murine SLE.

Journal Article (Journal Article;Review)

Antibodies to DNA occur prominently in systemic lupus erythematosus and play a central role in pathogenesis. Recent studies on the production of anti-DNA antibodies in both mouse and man suggest that this response can result from a variety of immunoregulatory disturbances of B and/or T cells. The immunogenic role of DNA as opposed to other self or foreign antigens remains unclear, however. Future studies will delineate the structure of anti-DNA antibodies and thereby determine the role of antigen drive in this response.

Full Text

Duke Authors

Cited Authors

  • Pisetsky, DS

Published Date

  • 1988

Published In

Volume / Issue

  • 2 / 1

Start / End Page

  • 31 - 34

PubMed ID

  • 2979813

International Standard Serial Number (ISSN)

  • 0258-851X


  • eng

Conference Location

  • Greece