The effect of dynamic mechanical compression on nitric oxide production in the meniscus.

Journal Article

The menisci play an important role in the biomechanics of the knee, and loss of meniscal function has been associated with progressive degenerative changes of the joint in rheumatoid arthritis as well as in osteoarthritis. However, little is known about the underlying mechanisms that link meniscal injury or degeneration to arthritis. Meniscal fibrochondrocytes respond to environmental mediators such as growth factors and cytokines, but the influence of mechanical stress on their metabolic activity is not well understood. Nitric oxide (NO) is believed to play a role in mechanical signal transduction, and there is also significant evidence of its role in cartilage and meniscus degeneration. The goal of this study was to determine if meniscal fibrochondrocytes respond to mechanical stress by increasing NO production in vitro.

Full Text

Duke Authors

Cited Authors

  • Fink, C; Fermor, B; Weinberg, JB; Pisetsky, DS; Misukonis, MA; Guilak, F

Published Date

  • July 2001

Published In

Volume / Issue

  • 9 / 5

Start / End Page

  • 481 - 487

PubMed ID

  • 11467897

International Standard Serial Number (ISSN)

  • 1063-4584

Digital Object Identifier (DOI)

  • 10.1053/joca.2001.0415


  • eng

Citation Source

  • PubMed