Immunochemical properties of anti-DNA antibodies in the sera of patients with Escherichia coli bacteremia.

Journal Article (Journal Article)

To assess the role of infection in anti-DNA antibody production, the DNA-binding activity of sera from patients with Escherichia coli bacteremia was analyzed. Among 8 patients with bacteremia documented by blood culture, 5 demonstrated increased levels of antibodies to single-stranded DNA from E. coli as measured by enzyme-linked immunosorbent assay. Sera from these patients also reacted with single-stranded DNA from other bacterial and mammalian species as well as certain synthetic polynucleotides including poly-dT and poly-dC. The isotype distribution of these antibodies and their avidity as assessed by competition enzyme-linked immunosorbent assay resembled, moreover, responses of patients with systemic lupus erythematosus. These results suggest that, during the course of infection with E. coli, some patients may produce antibodies with immunochemical properties similar to those arising in systemic lupus erythematosus.

Full Text

Duke Authors

Cited Authors

  • Robertson, CR; Pisetsky, DS

Published Date

  • 1992

Published In

Volume / Issue

  • 98 / 4

Start / End Page

  • 311 - 316

PubMed ID

  • 1422260

International Standard Serial Number (ISSN)

  • 1018-2438

Digital Object Identifier (DOI)

  • 10.1159/000236204


  • eng

Conference Location

  • Switzerland