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Microparticles as a source of extracellular DNA.

Publication ,  Journal Article
Pisetsky, DS; Gauley, J; Ullal, AJ
Published in: Immunol Res
April 2011

Microparticles are small membrane-bound vesicles that display pro-inflammatory and pro-thrombotic activities important in the pathogenesis of a wide variety of diseases. These particles are released from activated and dying cells and incorporate nuclear and cytoplasmic molecules for extracellular export. Of these molecules, DNA is a central autoantigen in systemic lupus erythematosus (SLE). As studies in our laboratory show, DNA occurs prominently in microparticles, translocating into these structures during apoptotic cell death. This DNA is antigenically active and can bind to lupus anti-DNA autoantibodies. These findings suggest that microparticles are an important source of extracellular DNA to serve as an autoantigen and autoadjuvant in SLE.

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Published In

Immunol Res

DOI

EISSN

1559-0755

Publication Date

April 2011

Volume

49

Issue

1-3

Start / End Page

227 / 234

Location

United States

Related Subject Headings

  • Toll-Like Receptors
  • Lupus Erythematosus, Systemic
  • Immunology
  • Humans
  • Extracellular Space
  • DNA
  • Cytokines
  • Cell-Derived Microparticles
  • Cell Line
  • Autoantigens
 

Citation

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Pisetsky, D. S., Gauley, J., & Ullal, A. J. (2011). Microparticles as a source of extracellular DNA. Immunol Res, 49(1–3), 227–234. https://doi.org/10.1007/s12026-010-8184-8
Pisetsky, David S., Julie Gauley, and Anirudh J. Ullal. “Microparticles as a source of extracellular DNA.Immunol Res 49, no. 1–3 (April 2011): 227–34. https://doi.org/10.1007/s12026-010-8184-8.
Pisetsky DS, Gauley J, Ullal AJ. Microparticles as a source of extracellular DNA. Immunol Res. 2011 Apr;49(1–3):227–34.
Pisetsky, David S., et al. “Microparticles as a source of extracellular DNA.Immunol Res, vol. 49, no. 1–3, Apr. 2011, pp. 227–34. Pubmed, doi:10.1007/s12026-010-8184-8.
Pisetsky DS, Gauley J, Ullal AJ. Microparticles as a source of extracellular DNA. Immunol Res. 2011 Apr;49(1–3):227–234.
Journal cover image

Published In

Immunol Res

DOI

EISSN

1559-0755

Publication Date

April 2011

Volume

49

Issue

1-3

Start / End Page

227 / 234

Location

United States

Related Subject Headings

  • Toll-Like Receptors
  • Lupus Erythematosus, Systemic
  • Immunology
  • Humans
  • Extracellular Space
  • DNA
  • Cytokines
  • Cell-Derived Microparticles
  • Cell Line
  • Autoantigens