The influence of Yaa on anti-DNA responses of B6-lpr mice.

Journal Article

The anti-DNA autoantibody responses of mice congenic for lpr and the Y-linked autoimmune accelerator (Yaa) genes were studied to evaluate genetic interactions in murine autoimmunity. Male B6-lpr, + mice failed to generate significant anti-DNA responses in comparison to B6-+, + mice. In contrast, B6-lpr mice bearing Yaa (B6-lpr, Yaa) had markedly increased IgG anti-DNA levels in comparison to both B6-+, + and B6-lpr, + mice. To determine whether anti-DNA levels reflected the overall B-cell response to lpr and Yaa, total IgG and IgM levels were also determined. This analysis demonstrated that the increase in IgG anti-DNA produced by mice with the Yaa gene was far greater than the increase in total IgG. Taken together, these results indicate that an impaired anti-DNA response related to one gene-determined mechanism for the development of autoimmunity does not preclude the response to another. Furthermore, it appears that the polyclonal B-cell activation during murine autoimmunity may be associated with the preferential expression of certain autoantibodies.

Full Text

Duke Authors

Cited Authors

  • Pisetsky, DS; Klatt, C; Dawson, D; Roths, JB

Published Date

  • December 1985

Published In

Volume / Issue

  • 37 / 3

Start / End Page

  • 369 - 376

PubMed ID

  • 3931946

International Standard Serial Number (ISSN)

  • 0090-1229

Language

  • eng

Conference Location

  • United States