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Role of Toll-like receptors in HMGB1 release from macrophages.

Publication ,  Journal Article
Pisetsky, DS; Jiang, W
Published in: Ann N Y Acad Sci
August 2007

HMGB1 is a nonhistone nuclear protein that can serve as a cytokine and activate innate immunity. The translocation of this molecule from the inside to the outside of cells is a critical event in inflammation, occurring following activation of certain Toll-like receptors (TLRs) as well as during the course of apoptotic as well as necrotic cell death. Because the kinetics of HMGB1 release differs from that of a conventional cytokine, it provides a broader therapeutic window and may be an important new target of therapy for inflammatory, autoimmune, and infectious diseases.

Duke Scholars

Published In

Ann N Y Acad Sci

DOI

ISSN

0077-8923

Publication Date

August 2007

Volume

1109

Start / End Page

58 / 65

Location

United States

Related Subject Headings

  • Toll-Like Receptors
  • Models, Immunological
  • Macrophages
  • Lymphocyte Activation
  • Ligands
  • Humans
  • HMGB1 Protein
  • General Science & Technology
  • Cell Death
  • Animals
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Pisetsky, D. S., & Jiang, W. (2007). Role of Toll-like receptors in HMGB1 release from macrophages. Ann N Y Acad Sci, 1109, 58–65. https://doi.org/10.1196/annals.1398.008
Pisetsky, David S., and Weiwen Jiang. “Role of Toll-like receptors in HMGB1 release from macrophages.Ann N Y Acad Sci 1109 (August 2007): 58–65. https://doi.org/10.1196/annals.1398.008.
Pisetsky DS, Jiang W. Role of Toll-like receptors in HMGB1 release from macrophages. Ann N Y Acad Sci. 2007 Aug;1109:58–65.
Pisetsky, David S., and Weiwen Jiang. “Role of Toll-like receptors in HMGB1 release from macrophages.Ann N Y Acad Sci, vol. 1109, Aug. 2007, pp. 58–65. Pubmed, doi:10.1196/annals.1398.008.
Pisetsky DS, Jiang W. Role of Toll-like receptors in HMGB1 release from macrophages. Ann N Y Acad Sci. 2007 Aug;1109:58–65.
Journal cover image

Published In

Ann N Y Acad Sci

DOI

ISSN

0077-8923

Publication Date

August 2007

Volume

1109

Start / End Page

58 / 65

Location

United States

Related Subject Headings

  • Toll-Like Receptors
  • Models, Immunological
  • Macrophages
  • Lymphocyte Activation
  • Ligands
  • Humans
  • HMGB1 Protein
  • General Science & Technology
  • Cell Death
  • Animals