Role of Toll-like receptors in HMGB1 release from macrophages.

Published

Journal Article

HMGB1 is a nonhistone nuclear protein that can serve as a cytokine and activate innate immunity. The translocation of this molecule from the inside to the outside of cells is a critical event in inflammation, occurring following activation of certain Toll-like receptors (TLRs) as well as during the course of apoptotic as well as necrotic cell death. Because the kinetics of HMGB1 release differs from that of a conventional cytokine, it provides a broader therapeutic window and may be an important new target of therapy for inflammatory, autoimmune, and infectious diseases.

Full Text

Duke Authors

Pisetsky, David Stephen

Cited Authors

Pisetsky, DS; Jiang, W

Published Date

August 2007

Published In

Annals of the New York Academy of Sciences

Volume / Issue

1109 /

Start / End Page

58 - 65

PubMed ID

17785291

Pubmed Central ID

17785291

Electronic International Standard Serial Number (EISSN)

1749-6632

International Standard Serial Number (ISSN)

0077-8923

Digital Object Identifier (DOI)

10.1196/annals.1398.008

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