Role of Toll-like receptors in HMGB1 release from macrophages.

Journal Article (Journal Article)

HMGB1 is a nonhistone nuclear protein that can serve as a cytokine and activate innate immunity. The translocation of this molecule from the inside to the outside of cells is a critical event in inflammation, occurring following activation of certain Toll-like receptors (TLRs) as well as during the course of apoptotic as well as necrotic cell death. Because the kinetics of HMGB1 release differs from that of a conventional cytokine, it provides a broader therapeutic window and may be an important new target of therapy for inflammatory, autoimmune, and infectious diseases.

Full Text

Duke Authors

Cited Authors

  • Pisetsky, DS; Jiang, W

Published Date

  • August 2007

Published In

Volume / Issue

  • 1109 /

Start / End Page

  • 58 - 65

PubMed ID

  • 17785291

International Standard Serial Number (ISSN)

  • 0077-8923

Digital Object Identifier (DOI)

  • 10.1196/annals.1398.008


  • eng

Conference Location

  • United States