Role of Toll-like receptors in HMGB1 release from macrophages.
Journal Article (Journal Article)
HMGB1 is a nonhistone nuclear protein that can serve as a cytokine and activate innate immunity. The translocation of this molecule from the inside to the outside of cells is a critical event in inflammation, occurring following activation of certain Toll-like receptors (TLRs) as well as during the course of apoptotic as well as necrotic cell death. Because the kinetics of HMGB1 release differs from that of a conventional cytokine, it provides a broader therapeutic window and may be an important new target of therapy for inflammatory, autoimmune, and infectious diseases.
Full Text
Duke Authors
Cited Authors
- Pisetsky, DS; Jiang, W
Published Date
- August 2007
Published In
Volume / Issue
- 1109 /
Start / End Page
- 58 - 65
PubMed ID
- 17785291
International Standard Serial Number (ISSN)
- 0077-8923
Digital Object Identifier (DOI)
- 10.1196/annals.1398.008
Language
- eng
Conference Location
- United States