Structure and function of anti-DNA autoantibodies derived from a single autoimmune mouse.
Publication
, Journal Article
Shlomchik, MJ; Aucoin, AH; Pisetsky, DS; Weigert, MG
Published in: Proc Natl Acad Sci U S A
December 1987
Four monoclonal anti-DNA antibodies derived from a single autoimmune MRL/lpr mouse were studied. Three of these antibodies showed similarities in DNA binding; the fourth had a much higher specific activity for single-stranded DNA and, in addition, was unique in binding double-stranded DNA and cardiolipin. Complete nucleotide sequences of heavy- and light-chain variable regions demonstrated that all four antibodies are clonally related. The sequences also showed numerous somatic mutations, the distribution of which suggests that positive selection by antigen operated on these clonally related autoantibodies.
Duke Scholars
Published In
Proc Natl Acad Sci U S A
DOI
ISSN
0027-8424
Publication Date
December 1987
Volume
84
Issue
24
Start / End Page
9150 / 9154
Location
United States
Related Subject Headings
- Mutation
- Molecular Sequence Data
- Mice, Mutant Strains
- Mice
- Lupus Erythematosus, Systemic
- Immunoglobulin Variable Region
- Genes, Immunoglobulin
- DNA
- Cardiolipins
- Base Sequence
Citation
APA
Chicago
ICMJE
MLA
NLM
Shlomchik, M. J., Aucoin, A. H., Pisetsky, D. S., & Weigert, M. G. (1987). Structure and function of anti-DNA autoantibodies derived from a single autoimmune mouse. Proc Natl Acad Sci U S A, 84(24), 9150–9154. https://doi.org/10.1073/pnas.84.24.9150
Shlomchik, M. J., A. H. Aucoin, D. S. Pisetsky, and M. G. Weigert. “Structure and function of anti-DNA autoantibodies derived from a single autoimmune mouse.” Proc Natl Acad Sci U S A 84, no. 24 (December 1987): 9150–54. https://doi.org/10.1073/pnas.84.24.9150.
Shlomchik MJ, Aucoin AH, Pisetsky DS, Weigert MG. Structure and function of anti-DNA autoantibodies derived from a single autoimmune mouse. Proc Natl Acad Sci U S A. 1987 Dec;84(24):9150–4.
Shlomchik, M. J., et al. “Structure and function of anti-DNA autoantibodies derived from a single autoimmune mouse.” Proc Natl Acad Sci U S A, vol. 84, no. 24, Dec. 1987, pp. 9150–54. Pubmed, doi:10.1073/pnas.84.24.9150.
Shlomchik MJ, Aucoin AH, Pisetsky DS, Weigert MG. Structure and function of anti-DNA autoantibodies derived from a single autoimmune mouse. Proc Natl Acad Sci U S A. 1987 Dec;84(24):9150–9154.
Published In
Proc Natl Acad Sci U S A
DOI
ISSN
0027-8424
Publication Date
December 1987
Volume
84
Issue
24
Start / End Page
9150 / 9154
Location
United States
Related Subject Headings
- Mutation
- Molecular Sequence Data
- Mice, Mutant Strains
- Mice
- Lupus Erythematosus, Systemic
- Immunoglobulin Variable Region
- Genes, Immunoglobulin
- DNA
- Cardiolipins
- Base Sequence