Immune responses to DNA in normal and aberrant immunity.

Journal Article (Journal Article;Review)

Because of structural microheterogeneity, DNA can exert powerful effects that lead to immune system activation as well as antibody induction. These activating effects resemble those ofendotoxin and result from sequences that occur much more commonly in bacterial DNA than in mammalian DNA. In contrast, mammalian DNA can inhibit the response to bacterial DNA as well as other stimuli and may serve a counterregulatory role during infection. The recognition of the immune effects of DNA is relevant to the pathogenesis of a variety of infectious and inflammatory diseases including systemic lupus erythematosus, a prototypic autoimmune disease characterized by anti-DNA autoantibodies.

Full Text

Duke Authors

Cited Authors

  • Pisetsky, DS

Published Date

  • 2000

Published In

Volume / Issue

  • 22 / 2-3

Start / End Page

  • 119 - 126

PubMed ID

  • 11339349

International Standard Serial Number (ISSN)

  • 0257-277X

Digital Object Identifier (DOI)

  • 10.1385/IR:22:2-3:119


  • eng

Conference Location

  • United States