Effect of anti-CD4 antibody treatment on inflammatory arthritis in MRL-lpr/lpr mice.

Journal Article (Journal Article)

MRL-lpr/lpr mice develop an inflammatory arthritis in association with other manifestations of autoimmunity. Although a variety of immune cell disturbances have been described in these mice, the relationship of these abnormalities to the pathogenesis of arthritis has not yet been determined; the role of T cells is especially unclear since synovial hypertrophy and joint erosions have been noted in some studies in the absence of a significant T cell infiltrate. Therefore, to determine if T cells are required for arthritis in MRL-lpr/lpr mice, we evaluated the effects of prolonged treatment with a monoclonal anti-CD4 antibody. Knee joints from treated mice had markedly reduced arthritis compared to saline-treated control animals as measured by the degree of synovial hypertrophy and inflammation. Nephritis in these mice was concomitantly reduced. In contrast, rheumatoid factor levels were not affected by CD4+ cell depletion, despite significant effects on anti-DNA. These results indicate that in MRL-lpr/lpr mice anti-CD4 therapy can inhibit arthritis, suggesting an important role of T cells in the pathogenesis of this lesion.

Full Text

Duke Authors

Cited Authors

  • Gilkeson, GS; Spurney, R; Coffman, TM; Kurlander, R; Ruiz, P; Pisetsky, DS

Published Date

  • August 1992

Published In

Volume / Issue

  • 64 / 2

Start / End Page

  • 166 - 172

PubMed ID

  • 1353712

International Standard Serial Number (ISSN)

  • 0090-1229

Digital Object Identifier (DOI)

  • 10.1016/0090-1229(92)90195-t


  • eng

Conference Location

  • United States