Effect of anti-CD4 antibody treatment on inflammatory arthritis in MRL-lpr/lpr mice.
Journal Article (Journal Article)
MRL-lpr/lpr mice develop an inflammatory arthritis in association with other manifestations of autoimmunity. Although a variety of immune cell disturbances have been described in these mice, the relationship of these abnormalities to the pathogenesis of arthritis has not yet been determined; the role of T cells is especially unclear since synovial hypertrophy and joint erosions have been noted in some studies in the absence of a significant T cell infiltrate. Therefore, to determine if T cells are required for arthritis in MRL-lpr/lpr mice, we evaluated the effects of prolonged treatment with a monoclonal anti-CD4 antibody. Knee joints from treated mice had markedly reduced arthritis compared to saline-treated control animals as measured by the degree of synovial hypertrophy and inflammation. Nephritis in these mice was concomitantly reduced. In contrast, rheumatoid factor levels were not affected by CD4+ cell depletion, despite significant effects on anti-DNA. These results indicate that in MRL-lpr/lpr mice anti-CD4 therapy can inhibit arthritis, suggesting an important role of T cells in the pathogenesis of this lesion.
- Gilkeson, GS; Spurney, R; Coffman, TM; Kurlander, R; Ruiz, P; Pisetsky, DS
- August 1992
Volume / Issue
- 64 / 2
Start / End Page
- 166 - 172
International Standard Serial Number (ISSN)
Digital Object Identifier (DOI)
- United States