Autoantibodies and their idiotypes.

Journal Article (Journal Article;Review)

Antinuclear antibodies occur prominently in systemic lupus erythematosus and serve as markers of underlying pathogenetic disturbances. Although these antibodies display features indicative of genetic control and in vivo selection by self-antigen, other mechanisms shaping the B-cell repertoire may influence their production. Provocative new animal models provide systems for analyzing the cellular and genetic disturbances promoting these responses, as well as the role of pathogenic specificities in inducing tissue injury.

Full Text

Duke Authors

Cited Authors

  • Pisetsky, DS

Published Date

  • October 1992

Published In

Volume / Issue

  • 4 / 5

Start / End Page

  • 635 - 643

PubMed ID

  • 1419497

International Standard Serial Number (ISSN)

  • 1040-8711


  • eng

Conference Location

  • United States