Expression of autoantibodies to recombinant (U1) RNP-associated 70K antigen in systemic lupus erythematosus.
Journal Article (Journal Article)
To determine the specificity of antibodies to the (U1) ribonucleoprotein antigen in systemic lupus erythematosus (SLE), patient sera were tested for binding to a recombinant human 70K antigen. By solid-phase immunoassay, we detected anti-70K reactivity in sera from 31 of 96 patients with systemic lupus erythematosus (SLE), demonstrating that anti-70K antibodies may occur in patients with SLE as well as other clinical diagnoses. In sequential sera from 2 of these patients, we found that anti-70K binding varied dramatically over the course of disease. The changes in anti-70K antibody levels did not correlate with clinical events nor evolving antibody reactivity with the Sm-specific antigens.
Full Text
Duke Authors
- Allen, Nancy Bates
- Bentley, Rex Colle
- Caldwell, David S.
- Keene, Jack Donald
- Pisetsky, David Stephen
- Rice, John Russell
- St. Clair, Eugene William
Cited Authors
- St Clair, EW; Query, CC; Bentley, R; Keene, JD; Polisson, RP; Allen, NB; Caldwell, DS; Rice, JR; Cox, C; Pisetsky, DS
Published Date
- February 1990
Published In
Volume / Issue
- 54 / 2
Start / End Page
- 266 - 280
PubMed ID
- 2104788
International Standard Serial Number (ISSN)
- 0090-1229
Digital Object Identifier (DOI)
- 10.1016/0090-1229(90)90088-8
Language
- eng
Conference Location
- United States