Developments in the scientific understanding of lupus.


Journal Article (Review)

Systemic lupus erythematosus is a systemic autoimmune disease characterized by the production of antinuclear antibodies (ANAs). Recent research into human and murine lupus suggests that disease susceptibility results from genetic polymorphisms regulating immune responses as well as impairing the clearance of apoptotic cells. Because the products of dead cells, including nucleic acids, have immunologic activity, this situation can promote antigen-driven ANA responses. Furthermore, immune complexes of ANAs can drive the production of proinflammatory cytokines, inducing the 'interferon signature', and intensifying disease. Together, these findings point to new genetic and immunologic markers of disease as well as targets for new therapies.

Full Text

Duke Authors

Cited Authors

  • Ardoin, SP; Pisetsky, DS

Published Date

  • January 2008

Published In

Volume / Issue

  • 10 / 5

Start / End Page

  • 218 -

PubMed ID

  • 18947369

Pubmed Central ID

  • 18947369

Electronic International Standard Serial Number (EISSN)

  • 1478-6362

International Standard Serial Number (ISSN)

  • 1478-6354

Digital Object Identifier (DOI)

  • 10.1186/ar2488


  • eng