Hyper-Ia antigen expression on B cells from B6-lpr/lpr mice correlates with manifestations of the autoimmune state.

Journal Article

To investigate the state of activation of B cells from mice with the lpr gene defect, membrane Ia antigen (mIa) expression was analyzed on B cells from B6-lpr/lpr (lpr) and control B6- +/-/+/- mice. B cells from lpr mice exhibited marked increases in levels of mIa as determined by flow cytometry using a monoclonal anti-I-Ab,d reagent. This increase, which was progressive with age, suggests that phenotypic alteration of B-cell mIa expression is a consequence of lpr gene action. Since B-cell activation manifest by elevated mIa expression may promote productive interactions with helper T cells, these observations suggest an important role for B-cell abnormalities in the etiology of lpr-induced autoimmune disease.

Full Text

Duke Authors

Cited Authors

  • Monroe, JG; Cambier, JC; Mody, EA; Pisetsky, DS

Published Date

  • January 1, 1985

Published In

Volume / Issue

  • 34 / 1

Start / End Page

  • 124 - 129

PubMed ID

  • 3871181

International Standard Serial Number (ISSN)

  • 0090-1229

Language

  • eng

Conference Location

  • United States