Autoantibodies and their significance.

Published

Journal Article (Review)

In systemic lupus erythematosus, autoantibodies have structural features that indicate in vivo selection by a T cell-dependent, antigen-driven process. The B-cell component of these responses resembles a conventional antibody response, whereas the T-cell component may involve diverse stimulatory mechanisms and levels of regulatory control. Characterizing T-cell epitopes of autoantigens has been difficult because these molecules are ubiquitous and exist inside the cells as multicomponent, macromolecular complexes. Autoantibodies can mediate disease manifestations by various mechanisms, with variable region structures determining the pattern and severity of tissue injury.

Full Text

Duke Authors

Cited Authors

  • Pisetsky, DS

Published Date

  • September 1, 1993

Published In

Volume / Issue

  • 5 / 5

Start / End Page

  • 549 - 556

PubMed ID

  • 8398606

Pubmed Central ID

  • 8398606

Electronic International Standard Serial Number (EISSN)

  • 1531-6963

International Standard Serial Number (ISSN)

  • 1040-8711

Language

  • eng