Genetic control of inflammatory arthritis in congenic lpr mice.

Journal Article (Journal Article)

To determine the genetic requirements for the development of inflammatory arthritis in MRL-lpr/lpr mice, clinical, serologic, and pathologic features of lpr/lpr and +/+ mice of MRL, B6, C3H, and AKR strains were studied. Arthritis was evaluated by histopathologic examination of the knee joint, while sera were tested for the presence of rheumatoid factor (RF) and anti-DNA activity by ELISA. Of the strains tested to age 7 months, only the MRL-lpr/lpr mice developed histologic evidence of arthritis. All lpr mice, however, produced both IgM RF and IgG RF, although amounts varied among strains. These results indicate that the lpr gene as well as another gene(s) in the MRL background are necessary for the development of inflammatory arthritis and that this lesion may be independent of RF production.

Full Text

Duke Authors

Cited Authors

  • Gilkeson, GS; Ruiz, P; Grudier, JP; Kurlander, RJ; Pisetsky, DS

Published Date

  • December 1989

Published In

Volume / Issue

  • 53 / 3

Start / End Page

  • 460 - 474

PubMed ID

  • 2805451

International Standard Serial Number (ISSN)

  • 0090-1229

Digital Object Identifier (DOI)

  • 10.1016/0090-1229(89)90008-1


  • eng

Conference Location

  • United States